Clinical Research Directory

Inclusion Criteria: * male patients with Fabry disease regardless of the clinical form of the disease; treated with enzyme replacement therapy or not (from the initial diagnosis). The definite diagnosis of Fabry disease will be established on the deficit of the activity of alpha galactosidase A (\<12%). A molecular genetic study is desirable but not mandatory, * patients aged 18 to 65, * giving their free and informed consent to participate, after information on the research. Exclusion Criteria: * persons placed under the protection of justice, * unaffiliated or non-beneficiary subject of a social security scheme.