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A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer
Sponsor: Regeneron Pharmaceuticals
Summary
This study will evaluate REGN5093 for the treatment of Non-Small Cell Lung Cancer (NSCLC) with MET alteration. The main purpose of this study is to determine the safety, tolerability, and effectiveness of REGN5093. The study has two phases. The main goal of Phase 1 is to determine a safe dose(s) of REGN5093. The main goal of phase 2 of the study is to use the REGN5093 drug dose(s) found in Phase 1 to see how well REGN5093 works to shrink tumors. The study is looking at several other research questions, including: * Side effects that may be experienced by people taking REGN5093 * How REGN5093 works in the body * How much REGN5093 is present in the blood * To see if REGN5093 works to reduce or delay the progression of cancer * How long it takes REGN5093 to work in the body
Official title: A Phase 1/2 Study of REGN5093 in Patients With MET-Altered Advanced Non-Small Cell Lung Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
231
Start Date
2020-01-07
Completion Date
2032-04-22
Last Updated
2026-03-18
Healthy Volunteers
No
Conditions
Interventions
REGN5093
Intravenous (IV) infusion. There will be a series of dose escalation cohorts followed by an expansion phase.
Locations (40)
University of Alabama at Birmingham
Birmingham, Alabama, United States
University of California Irvine Medical Center - Bldg 56, RT81, Rm 241
Orange, California, United States
Georgetown University Medical Center
Washington D.C., District of Columbia, United States
Moffitt Cancer Center - McKinley Drive
Tampa, Florida, United States
University of Kentucky, Markey Cancer Center Clinical Research Organization
Lexington, Kentucky, United States
DNU_Massachusetts General Hospital_DNU
Boston, Massachusetts, United States
Dana Farber Harvard Cancer Center Consortium
Boston, Massachusetts, United States
Henry Ford Health System
Detroit, Michigan, United States
Washington University School of Medicine
St Louis, Missouri, United States
NYU Cancer Institute
New York, New York, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Duke Cancer Center
Durham, North Carolina, United States
Stephenson Cancer Center
Oklahoma City, Oklahoma, United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States
University of Pittsburgh UPMC - Clinical Research Services
Pittsburgh, Pennsylvania, United States
Harold C. Simmons Comprehensive Cancer Center
Dallas, Texas, United States
The University of Texas MD Anderson Cancer Center
Houston, Texas, United States
Centre Georges Francois Leclerc
Dijon, Bourgogne-Franche-Comté, France
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
Rennes, Bretange, France
Centre Francois Baclesse (CFB)
Caen, Normandy, France
Institut Bergonie
Bordeaux, Nouvelle-Aquitaine, France
Centre Hospitalier Universitaire de Grenoble
Grenoble, France
Centre Hospitalier Regional Universitaire (CHRU) Montpellier Arnaud de Villeneuve
Montpellier, France
National Cancer Center
Gyeonggi-do, Gyeonggi-do, South Korea
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
The Catholic University Of Korea St. Vincent's Hospital
Suwon, Gyeonggi-do, South Korea
Ajou University Hospital
Suwon, Gyeonggi-do, South Korea
Haeundae Paik Hospital
Pusan, Gyeongsangnam-do, South Korea
Chonnam National University Hwasun Hospital
Hwasun, Jeollanam-do, South Korea
Gachon University Gil Medical Center
Incheon, Namdong-gu, South Korea
Chungbuk National University Hospital
Cheongju-si, North Chungcheong, South Korea
Pusan National University Hospital
Busan, South Korea
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Seol St. Mary's Hospital
Seoul, South Korea
Boramae Medical Center
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital
Seoul, South Korea