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ACTIVE NOT RECRUITING
NCT04084249
NA

ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention Trial

Sponsor: Claus Lindbjerg Andersen

View on ClinicalTrials.gov

Summary

IMPROVE-IT2 is a randomized multicenter trial comparing the outcomes of ctDNA guided post-operative surveillance and standard-of-care CT-scan surveillance. The hypothesis of this study is that ctDNA guided post-operative surveillance combining ctDNA and radiological assessments could result in earlier detection of recurrent disease and identify more patients eligible for curative treatment.

Official title: Implementing Non-invasive Circulating Tumor DNA Analysis to Optimize the Operative and Postoperative Treatment for Patients With Colorectal Cancer - Intervention Trial 2

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

359

Start Date

2020-01-01

Completion Date

2028-06-30

Last Updated

2024-07-09

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

ctDNA-analysis

Minimally-invasive blood-based analysis of circulating tumor DNA (ctDNA).

OTHER

Intensified Follow-up Schedule

PET/CT-scans every 3. month

Locations (10)

Herlev Hospital

Herlev, Capital Region of Denmark, Denmark

Gødstrup Hospital

Herning, Central Jutland, Denmark

Regional Hospital Horsens

Horsens, Central Jutland, Denmark

Regional Hospital Randers

Randers, Central Jutland, Denmark

Aalborg University Hospital

Aalborg, North Denmark, Denmark

Odense University Hospital

Odense, The Region of Southern Denmark, Denmark

Aarhus University Hospital

Aarhus, Denmark

Bispebjerg Hospital

Copenhagen, Denmark

Zealand University Hospital

Køge, Denmark

Regional Hospital Viborg

Viborg, Denmark