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ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention Trial
Sponsor: Claus Lindbjerg Andersen
Summary
IMPROVE-IT2 is a randomized multicenter trial comparing the outcomes of ctDNA guided post-operative surveillance and standard-of-care CT-scan surveillance. The hypothesis of this study is that ctDNA guided post-operative surveillance combining ctDNA and radiological assessments could result in earlier detection of recurrent disease and identify more patients eligible for curative treatment.
Official title: Implementing Non-invasive Circulating Tumor DNA Analysis to Optimize the Operative and Postoperative Treatment for Patients With Colorectal Cancer - Intervention Trial 2
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
359
Start Date
2020-01-01
Completion Date
2028-06-30
Last Updated
2024-07-09
Healthy Volunteers
No
Conditions
Interventions
ctDNA-analysis
Minimally-invasive blood-based analysis of circulating tumor DNA (ctDNA).
Intensified Follow-up Schedule
PET/CT-scans every 3. month
Locations (10)
Herlev Hospital
Herlev, Capital Region of Denmark, Denmark
Gødstrup Hospital
Herning, Central Jutland, Denmark
Regional Hospital Horsens
Horsens, Central Jutland, Denmark
Regional Hospital Randers
Randers, Central Jutland, Denmark
Aalborg University Hospital
Aalborg, North Denmark, Denmark
Odense University Hospital
Odense, The Region of Southern Denmark, Denmark
Aarhus University Hospital
Aarhus, Denmark
Bispebjerg Hospital
Copenhagen, Denmark
Zealand University Hospital
Køge, Denmark
Regional Hospital Viborg
Viborg, Denmark