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Perioperative Lidocaine and Ketamine in Abdominal Surgery
Sponsor: The Cleveland Clinic
Summary
The investigators propose to test the hypothesis that perioperative infusions of lidocaine and/or ketamine reduce opioid consumption and pain scores in adults recovering from elective inpatient abdominal surgery.
Official title: Lidocaine and Ketamine in Abdominal Surgery
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
420
Start Date
2019-10-15
Completion Date
2025-12
Last Updated
2025-05-21
Healthy Volunteers
Yes
Conditions
Interventions
Lidocaine and ketamine
Perioperative lidocaine and ketamine infusion (see below for dosages and timings)
Lidocaine
Perioperative lidocaine infusion (1.5 mg/kg bolus followed by an infusion of 2 mg/kg/hour based on actual body weight; the bolus and infusion will be started after anesthesia induction and before surgical incision, and continued until 1 hour after transfer from the operating room to the PACU)
Ketamine
Perioperative ketamine infusion (0.5 mg/kg bolus followed by an infusion of 0.3 mg/kg/hour based on actual body weight; the bolus and infusion will be started after anesthesia induction and before surgical incision, and continued until 1 hour after transfer from the operating room to the PACU)
Placebo
Perioperative placebo infusion (normal saline)
Locations (1)
Cleveland Clinic Florida
Weston, Florida, United States