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Screening Nasopharyngeal Carcinoma With EBV Associated Biomarkers in Zhongshan City
Sponsor: Zhongshan People's Hospital, Guangdong, China
Summary
All participants will be tested for EBV associated biomarkers, including EBNA1-IgA, VCA-IgA, BNLF2b total antibodies (P85-Ab) et al. For all male participants and P85-Ab positive female participants, EBV DNA in plasma will be tested. Screening positive participants will be followed up annually. All subjects will also be followed by record linkage to Cancer Register and Population Register.
Official title: Searching for Early Detection Biomarkers of Nasopharyngeal Carcinoma in Zhongshan City
Key Details
Gender
All
Age Range
30 Years - 69 Years
Study Type
OBSERVATIONAL
Enrollment
40000
Start Date
2020-04-01
Completion Date
2027-12-31
Last Updated
2023-07-13
Healthy Volunteers
Yes
Conditions
Interventions
Blood and saliva
Collect blood and saliva samples from participants
P85-Ab, EBNA1-IgA, VCA-IgA and EBV DNA
Detect P85-Ab, EBNA1-IgA, VCA-IgA for all participants, and detect EBV DNA for all male participants and P85-Ab positive female participants.
Fiberoptic endoscopy and biopsy
Screening participants will refer to fiberoptic endoscopy and biospy
Locations (2)
Zhongshan People's Hospital
Zhongshan, Guangdong, China
Wuzhou Red Cross Hospital
Wuzhou, Guangxi, China