Clinical Research Directory

Inclusion Criteria: * Aim 1 (CD participants) 1. Aged 8-70 years 2. Undergoing first surgical distal (ileal) small bowel resection for structuring (B2 phenotype) Crohn's disease as determined by CTE or MRE or ileocolonoscopy 3. English speaking * Aim 2 (CD participants) 1. Age 8 to 70 years 2. Uncomplicated inflammatory small bowel CD based on clinical CTE or MRE or ileocolonoscopy performed within 6 months prior to enrollment (CD participants only) 3. English speaking * Aim 2 (Control participants) 1. Age 8 to 70 years 2. English speaking Exclusion Criteria: * Aim1 (CD participants) 1. B1 or B3 (i.e., fistula, abscess, phlegmon/inflammatory mass) CD phenotype 2. Prior small bowel surgery, including but not limited to surgical resection, stricturoplasty, or endoscopic treatment of a small bowel stricture 3. Anything to eat or drink within 4 hours of study visit (participants may take their required medications with a little water) 4. Known pregnancy (Note: Institutional policies/procedures will be followed for pregnancy screening) 5. Contraindication for MRI (e.g., surgical implant, claustrophobia). Note: To be determined based on local procedures. * Aim 2 (CD participants) 1. Stenotic ileocecal valve at colonoscopy 2. Prior small bowel surgery, including but not limited to surgical resection, stricturoplasty, or endoscopic treatment of a small bowel stricture 3. Anything to eat or drink within 4 hours of study visit (participants may take their required medications with a little water) 4. Known pregnancy (Note: Institutional policies/procedures will be followed for pregnancy screening) 5. Contraindication for MRI (e.g., surgical implant, claustrophobia). Note: To be determined based on local procedures. * Aim 2 (Control participants) 1. Any known gastrointestinal tract disease 2. Any known inflammatory/autoimmune disease involving another organ system (e.g., rheumatoid arthritis, scleroderma, multiple sclerosis). 3. Fecal calprotectin level of ˃100 mcg.gm will be excluded from further analysis and replaced.