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Closed Loop Ventilation With High Tidal Volumes and Safe Transpulmonary Pressure in COPD (COPD-SAFE)
Sponsor: Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Summary
This study evaluates the safety and efficacy of high tidal volumes generated by "Adapted Support Ventilation (ASV) mode' in mechanically ventilated severe COPD patients. Every patient will be ventilated consecutively with ASV and Volume Control (VC) modes at 2 different levels of minute volume in 2 sets. ASV mode is expected to be safe measured by adequate inspiratory transpulmonary pressures and expected to be as effective as VC mode with lower intrinsic positive end expiratory pressure (iPEEP) levels.
Official title: Does Automatically Generated Tidal Volumes With Closed-loop Ventilation Leads to Safe Transpulmonary Pressures in Intubated Chronic Obstructive Pulmonary Disease Patients?
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2024-12
Completion Date
2025-02
Last Updated
2024-10-15
Healthy Volunteers
No
Conditions
Interventions
Minute volume target of 100%
Patients will be ventilated to reach minute volume target of %100 (100 ml per ideal body weight).
Minute volume target to reach PaCO2 less than 45% (high tidal volume)
Patients will be ventilated to reach minute volume target associated with PaCO2 less than 45%.
Locations (1)
Izmir Dr. Suat Seren Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit
Izmir, Yenisehir, Turkey (Türkiye)