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PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients
Sponsor: Beth Israel Deaconess Medical Center
Summary
Our objective is to find an effective prophylactic intervention by evaluating IV acetaminophen's impact in reducing the frequency of postoperative delirium, one of the most common and detrimental complications of cardiac surgery in older adults.
Official title: PANDORA: Scheduled Prophylactic 6-hourly Intravenous Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
900
Start Date
2020-08-11
Completion Date
2026-03-04
Last Updated
2026-01-12
Healthy Volunteers
No
Interventions
IV acetaminophen
use of IV tylenol for pain
Placebo
Volume of the placebo (saline) will match that of IV acetaminophen at 100ml 0.9% NaCl
Locations (10)
University of Alabama at Birmingham
Birmingham, Alabama, United States
University of California Irvine
Irvine, California, United States
University of California Los Angeles
Los Angeles, California, United States
Yale University/Yale New Haven Hospital
New Haven, Connecticut, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Columbia University Irving Medical Center
New York, New York, United States
Albert Einstein College of Medicine- Montefiore
The Bronx, New York, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States