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Berries, Inflammation, and Gut Microbiome
Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology
Summary
The primary objectives are to characterize changes in indices of systemic and gut inflammation, assess host- and microbial-derived metabolite pools, and describe and link functional metagenomics and metatranscriptomic alterations in the gut microbiome with metabolite and inflammatory outcomes after acute (24hr) and chronic (4 week) intake of anthocyanins and ellagitannins from strawberry and red raspberries compared to a control diet (negative control), FOS (positive control, non-polyphenol, carbohydrate-based fermentable fiber/pre-biotic), or combination diet (berry composite + FOS) in human participants with low-grade inflammation.
Official title: Polyphenols and Human Gut Microbiome Interactions: Role of in Ameliorating Inflammation
Key Details
Gender
All
Age Range
20 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
105
Start Date
2019-10-07
Completion Date
2026-10-01
Last Updated
2026-03-25
Healthy Volunteers
Yes
Conditions
Interventions
Mixed berries
Strawberry and red raspberry
FOS
Fructo-oligosaccharide
Control
Placebo similar in color to mixed berry supplement without any polyphenols
Combination
Mixed berry composite + FOS
Locations (1)
Clinical Nutrition Research Center
Chicago, Illinois, United States