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ACTIVE NOT RECRUITING
NCT04100200
NA

Berries, Inflammation, and Gut Microbiome

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

View on ClinicalTrials.gov

Summary

The primary objectives are to characterize changes in indices of systemic and gut inflammation, assess host- and microbial-derived metabolite pools, and describe and link functional metagenomics and metatranscriptomic alterations in the gut microbiome with metabolite and inflammatory outcomes after acute (24hr) and chronic (4 week) intake of anthocyanins and ellagitannins from strawberry and red raspberries compared to a control diet (negative control), FOS (positive control, non-polyphenol, carbohydrate-based fermentable fiber/pre-biotic), or combination diet (berry composite + FOS) in human participants with low-grade inflammation.

Official title: Polyphenols and Human Gut Microbiome Interactions: Role of in Ameliorating Inflammation

Key Details

Gender

All

Age Range

20 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

105

Start Date

2019-10-07

Completion Date

2026-10-01

Last Updated

2026-03-25

Healthy Volunteers

Yes

Interventions

DIETARY_SUPPLEMENT

Mixed berries

Strawberry and red raspberry

DIETARY_SUPPLEMENT

FOS

Fructo-oligosaccharide

DIETARY_SUPPLEMENT

Control

Placebo similar in color to mixed berry supplement without any polyphenols

DIETARY_SUPPLEMENT

Combination

Mixed berry composite + FOS

Locations (1)

Clinical Nutrition Research Center

Chicago, Illinois, United States