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The GBA Multimodal Study in Parkinson's Disease
Sponsor: Pacific Parkinson's Research Centre
Summary
This study plans to analyze the molecular and clinical mechanisms of the relationship between the GBA mutations and Parkinson's disease. This will be assessed through the use of advanced neuroimaging techniques called PET (positron emission tomography) to study the accumulation of the tau protein and the dysfunction of acetylcholine and dopamine in the brain of people with a mutation in the GBA gene, with and without Parkinson's disease. The ingestigators will also use a technology-based assessment to study the typing patterns as possible biomarkers of early motor dysfunctions.
Official title: Multimodal Molecular Imaging and Biometric Analysis in GBA-PD and Asymptomatic GBA-mutation Carriers
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
25
Start Date
2019-05-01
Completion Date
2025-12-30
Last Updated
2025-05-31
Healthy Volunteers
No
Interventions
PET scan
3 PET scans to analyze the dopamine metabolism, acetylcholine and tau protein deposition in the brain.
neuroQWERTY
Analysis of free-text typing in a computer and/or a touch-screen device.
Locations (3)
Oregon Health & Science University
Portland, Oregon, United States
University of Washington
Seattle, Washington, United States
Pacific Parkinson's Research Centre | University of British Columbia
Vancouver, British Columbia, Canada