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Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)
Sponsor: University of Leeds
Summary
A multi-centre observational study recruiting prospective and retrospective cohorts of patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The primary aim is to find genetic determinants of GCA and PMR susceptibility, in order to yield novel insights into disease pathogenesis. A subset of the retrospective cohort is also enrolled in a post-marketing surveillance registry of patients eligible for, or receiving tocilizumab, to treat their relapsing or refractory GCA.
Official title: UK GCA Consortium: Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
OBSERVATIONAL
Enrollment
4500
Start Date
2005-06-10
Completion Date
2028-03-31
Last Updated
2025-03-30
Healthy Volunteers
No
Locations (76)
Queen Elizabeth The Queen Mother Hospital
Canterbury, Kent, United Kingdom
Whiston Hospital
Prescot, Merseyside, United Kingdom
Nevill Hall Hospital, Aneurin Bevan University Health Board
Abergavenny, United Kingdom
Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust
Aylesbury, United Kingdom
Betsi Cadwaladr University Health Board
Bangor, United Kingdom
Barnsley Hospital, Barnsley Hospital NHS Foundation Trust
Barnsley, United Kingdom
Basildon University Hospital, Basildon and Thurrock University Hospitals NHS Foundation Trust
Basildon, United Kingdom
Basingstoke and North Hampshire Hospital, Hampshire Hospitals NHS Foundation Trust
Basingstoke, United Kingdom
Royal National Hospital for Rheumatic Diseases, Royal United Hospitals Bath NHS Foundation Trust
Bath, United Kingdom
Birmingham Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom
Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom
Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust
Bristol, United Kingdom
Queen's Hospital, University Hospitals of Derby and Burton NHS Foundation Trust
Burton-on-Trent, United Kingdom
West Suffolk Hospital, West Suffolk NHS Foundation Trust
Bury St Edmunds, United Kingdom
Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
Chelsea and Westminster Hospital, Chelsea and Westminster Hospital NHS Foundation Trust
Chelsea, United Kingdom
West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust
Chelsea, United Kingdom
Ashford and St Peter's Hospitals, Ashford & St Peter's Hospitals NHS Foundation Trust
Chertsey, United Kingdom
Countess of Chester Hospital, Countess of Chester NHS Foundation Trust
Chester, United Kingdom
Christchurch Hospital, University Hospitals Dorset NHS Foundation Trust
Christchurch, United Kingdom
Croydon University Hospital, Croydon Health Service NHS Trust
Croydon, United Kingdom
Darlington Memorial Hospital, County Durham and Darlington NHS Foundation Trust
Darlington, United Kingdom
Royal Derby Hospital, University Hospitals of Derby and Burton NHS Foundation Trust
Derby, United Kingdom
Doncaster Royal Infirmary, Doncaster and Bassetlaw Hospitals NHS Foundation Trust
Doncaster, United Kingdom
Ninewells Hospital and Medical School, NHS Tayside
Dundee, United Kingdom
Royal Devon and Exeter Hospital, Royal Devon and Exeter NHS Foundation Trust
Exeter, United Kingdom
Frimley Park Hospital, Frimley Park Hospital NHS Foundation Trust
Frimley, United Kingdom
Gateshead Queen Elizabeth Hospital, Gateshead Health NHS Foundation Trust
Gateshead, United Kingdom
Inverclyde Royal Hospital, NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
Royal Alexandra Hospital, NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
Vale of Leven Hospital, NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
James Paget Hospital, James Paget University Hospitals NHS Foundation Trust
Great Yarmouth, United Kingdom
Royal Surrey County Hospital, Royal Surrey County Hospital NHS Foundation Trust
Guildford, United Kingdom
Harrogate and District Hospital, Harrogate and District NHS Foundation Trust
Harrogate, United Kingdom
Hull Royal Infirmary, Hull and East Yorkshire NHS Trust
Hull, United Kingdom
Ipswich Hospital, East Suffolk and North Essex NHS Foundation Trust
Ipswich, United Kingdom
Airedale General Hospital, Airedale NHS Foundation Trust
Keighley, United Kingdom
Westmorland General Hospital, University Hospitals of Morecambe Bay NHS Foundation Trust
Kendal, United Kingdom
The Queen Elizabeth Hospital, The Queen Elizabeth Hospital Kings Lynn NHS Foundation Trust
Kings Lynn, United Kingdom
Royal Lancaster Infirmary, University Hospitals of Morecambe NHS Foundation Trust
Lancaster, United Kingdom
Chapel Allerton Hospital, Leeds Teaching Hospitals NHS Foundation Trust
Leeds, United Kingdom
Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust
Leicester, United Kingdom
Aintree University Hospital, Aintree University Hospitals NHS Trust
Liverpool, United Kingdom
Royal Glamorgan Hospital, Cwm Taf University Health Board
Llantrisant, United Kingdom
Hammersmith Hospital, Imperial College Healthcare NHS Trust
London, United Kingdom
King's College Hospital, King's College Hospital NHS Foundation Trust, London
London, United Kingdom
Royal Free Hospital, Royal Free NHS Foundation Trust
London, United Kingdom
St George's Hospital, St George's University Hospitals NHS Foundation Trust
London, United Kingdom
University College London Hospital, University College London NHS Foundation Trust
London, United Kingdom
Manchester Royal Infirmary, Manchester University NHS Foundation Trust
Manchester, United Kingdom
Arrowe Park Hospital, Wirral University Hospital NHS Foundation Trust
Metropolitan Borough of Wirral, United Kingdom
Freeman Hospital, The Newcastle-upon-Tyne Hospitals NHS Foundation Trust
Newcastle, United Kingdom
North Tyneside General Hospital, Northumbria Healthcare NHS Foundation Trust
North Shields, United Kingdom
Northampton General Hospital, Northampton General Hospital NHS Trust
Northampton, United Kingdom
Norfolk and Norwich University Hospital, Norfolk and Norwich University Hospitals NHS Foundation Trust
Norwich, United Kingdom
Queens Medical Centre, Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom
Oxford Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Trust
Oxford, United Kingdom
Peterborough City Hospital, North West Anglia NHS Foundation Trust
Peterborough, United Kingdom
Derriford Hospital, University Hospital Plymouth NHS Trust
Plymouth, United Kingdom
Poole Hospital, University Hospitals Dorset NHS Foundation Trust
Poole, United Kingdom
Minerva Health Centre, Lancashire and South Cumbria NHS Foundation Trust
Preston, United Kingdom
Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust
Preston, United Kingdom
Salford Royal Hospital, Salford Royal NHS Foundation Trust
Salford, United Kingdom
Scarborough General Hospital, York and Scarborough Teaching Hospitals NHS Foundation Trust
Scarborough, United Kingdom
Southend University Hospital, Southend University Hospital NHS Foundation Trust
Southend-on-Sea, United Kingdom
Lister Hospital, East and North Hertfordshire NHS Trust
Stevenage, United Kingdom
Haywood Hospital, Midlands Partnership NHS Foundation Trust
Stoke-on-Trent, United Kingdom
Great Western Hospital, The Great Western Hospitals NHS Foundation Trust
Swindon, United Kingdom
Torbay Hospital, Torbay and South Devon NHS Foundation Trust
Torquay, United Kingdom
Royal Cornwall Hospital, Royal Cornwall Hospitals NHS Trust
Truro, United Kingdom
Pinderfields Hospital, Mid Yorkshire Hospitals NHS Trust
Wakefield, United Kingdom
Warrington Hospital, Warrington and Halton Hospitals NHS Foundation Trust
Warrington, United Kingdom
Warwick Hospital, South Warwickshire NHS Foundation Trust
Warwick, United Kingdom
Royal Hampshire County Hospital, Hampshire Hospitals NHS Foundation Trust
Winchester, United Kingdom
University Hospital Wishaw, NHS Lanarkshire
Wishaw, United Kingdom
York Hospital, York and Scarborough Teaching Hospitals NHS Foundation Trust
York, United Kingdom