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Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis
Sponsor: Boston Children's Hospital
Summary
In this research study we want to learn more about the characteristics of neutrophils that are present in the blood and secretions from a breathing tube of patients with sepsis. Sepsis is a severe type of infection, affecting various parts of the body. Neutrophils are a type of white blood cell that are part of the body's immune system. Even though neutrophils are important in getting rid of germs, they also may be harmful to parts of the body by causing injury in the lungs in patients with sepsis. Neutrophils can change their character in sepsis. Because of this, it is important for doctors to know what kind of neutrophils are in the blood and secretions from the breathing tube of patients with sepsis so that they can work to develop therapies to prevent these cells from being harmful.
Key Details
Gender
All
Age Range
2 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
75
Start Date
2020-09-01
Completion Date
2026-12-31
Last Updated
2026-03-17
Healthy Volunteers
No
Conditions
Interventions
Sepsis
Sepsis patients in the ICU with a breathing tube
Locations (1)
Boston Children's Hospital
Boston, Massachusetts, United States