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Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy
Sponsor: University Hospitals of Derby and Burton NHS Foundation Trust
Summary
The aim of this study is to assess whether, omitting further axillary treatment (ALND and ART) for patients with early stage breast cancer and axillary nodal metastases on needle biopsy, who after NACT have no residual cancer in the lymph nodes on sentinel node biopsy, is non-inferior to axillary treatment in terms of disease free survival (DFS) and results in reduced risk of lymphoedema at 5 years.
Official title: ATNEC - Axillary Management in T1-3N1M0 Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases at Presentation After Neoadjuvant Chemotherapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1900
Start Date
2021-02-26
Completion Date
2030-02-28
Last Updated
2026-03-30
Healthy Volunteers
No
Interventions
Axillary lymph node dissection
Participants will undergo removal of at least level I and II axillary lymph nodes.
Axillary radiotherapy
Axillary radiotherapy will be delivered as per the Radiotherapy Trials Quality Assurance (RTTQA) guidelines.
Breast or chest wall radiotherapy
Breast or chest wall radiotherapy will be delivered as per the Radiotherapy Trials Quality Assurance (RTTQA) guidelines.
Locations (98)
St Vincent's University Hospital - St Vincent's Healthcare Group
Dublin, Ireland
St Luke's Hospital - St Luke's Radiation Oncology Network
Dublin, Ireland
Beaumont Hospital - Royal College of Surgeons in Ireland
Dublin, Ireland
Galway University Hospitals - Saolta University Health Care Group
Galway, Ireland
Airedale General Hospital - Airedale NHS Foundation Trust
Keighley, BD20 6TD, United Kingdom
Cumberland Infirmary - North Cumbria Integrated Care NHS Foundation Trust
Carlisle, CA2 7HY, United Kingdom
Frimley Park Hospital - Frimley Health NHS Foundation Trust
Camberley, GU16 7UJ, United Kingdom
Raigmore Hospital - NHS Highland
Inverness, IV2 3UJ, United Kingdom
James Paget Hospital -James Paget University Hospitals NHS Foundation Trust
Great Yarmouth, NR31 6LA, United Kingdom
Royal Berkshire Hospital - Royal Berkshire NHS Foundation Trust
Reading, RG1 5AN, United Kingdom
Macclesfield District General Hospital - East Cheshire NHS Trust
Macclesfield, SK10 3BL., United Kingdom
Royal Shrewsbury Hospital -The Shrewsbury and Telford Hospitals NHS Trust
Shrewsbury, SY3 8XQ, United Kingdom
Aberdeen Royal Infirmary - NHS Grampian
Aberdeen, United Kingdom
Ashford Hospital - Ashford and St Peter's Hospitals NHS Foundation Trust
Ashford, United Kingdom
Tameside General Hospital- Tameside and Glossop Integrated Care NHS Foundation Trust
Ashton-under-Lyne, United Kingdom
University Hospital Crosshouse - NHS Ayrshire and Arran
Ayr, United Kingdom
Basildon University Hospital - Mid and South Essex NHS Foundation Trust
Basildon, United Kingdom
Belfast City Hospital - Belfast Health and Social Care Trust
Belfast, United Kingdom
QEHB- University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom
City Hospital -Sandwell and West Birmingham NHS Trust
Birmingham, United Kingdom
Blackpool Victoria Hospital - Blackpool Teaching Hospitals NHS Foundation Trust
Blackpool, United Kingdom
Royal Bolton Hospital - Bolton NHS Foundation Trust
Bolton, United Kingdom
St Luke's Hospital - Bradford Teaching Hospitals NHS Foundation Trust
Bradford, United Kingdom
Royal Sussex County Hospital - University Hospitals Sussex NHS Foundation Trust
Brighton, United Kingdom
Southmead Hospital - North Bristol NHS Trust
Bristol, United Kingdom
Burnley General Hospital- East Lancashire Hospitals NHS Trust
Burnley, United Kingdom
Addenbrooke's Hospital - Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
Cheltenham General Hospital - Gloucestershire General Hospitals NHS Foundation Trust
Cheltenham, United Kingdom
Countess of Chester Hospital - Countess of Chester Hospital NHS Trust
Chester, United Kingdom
Leighton Hospital - Mid Cheshire NHS Foundation Trust
Crewe, United Kingdom
Darlington Memorial Hospital - County Durham and Darlington NHS Foundation Trust
Darlington, United Kingdom
Royal Derby Hospital- University Hospitals of Derby and Burton NHS Foundation Trust
Derby, United Kingdom
Doncaster Royal Infirmary - Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust
Doncaster, United Kingdom
Russell's Hall Hospital - The Dudley Group NHS Foundation Trust
Dudley, United Kingdom
Dumfries and Galloway Royal Infirmary - NHS Dumfries and Galloway
Dumfries, United Kingdom
Queen Margert Hospital - NHS Fife
Dunfermline, United Kingdom
University Hospital Hairmyres - NHS Lanarkshire
East Kilbride, United Kingdom
Western General Hospital -NHS Lothian
Edinburgh, United Kingdom
Royal Devon & Exeter Hospital - Royal Devon and Exeter NHS Foundation Trust
Exeter, United Kingdom
Queen Elizabeth Hospital - Gateshead Health NHS Foundation Trust
Gateshead, United Kingdom
Beatson West of Scotland Cancer Centre - Greater Glasgow Health Board
Glasgow, United Kingdom
Royal Surrey County Hospital - Royal Surrey NHS Foundation Trust
Guildford, United Kingdom
Harrogate District Hospital - Harrogate and District NHS Foundation Trust
Harrogate, United Kingdom
Hereford County Hospital- Wye Valley NHS Trust
Hereford, United Kingdom
Wycombe Hospital - Buckinghamshire Healthcare NHS Trust
High Wycombe, United Kingdom
Huddersfield Royal Infirmary- Calderdale and Huddersfield NHS Foundation Trust
Huddersfield, United Kingdom
Castle Hill Hospital - Hull University Teaching Hospitals NHS Trust
Hull, United Kingdom
Ipswich Hospital - East Suffolk and North Essex NHS Foundation Trust
Ipswich, United Kingdom
West Middlesex University Hospital - Chelsea and Westminster Hospital NHS Foundation Trust
Isleworth, United Kingdom
Royal Lancaster Infirmary - University Hospitals of Morecambe Bay NHS Foundation Trust
Lancaster, United Kingdom
Forth Valley Royal Hospital - NHS Forth Valley
Larbert, United Kingdom
St James's University Hospital - Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
Glenfield Hospital - University Hospitals of Leicester NHS Trust
Leicester, United Kingdom
Lincoln County Hospital - United Lincolnshire Hospitals NHS Trust
Lincoln, United Kingdom
Prince Phillip Hospital -Hywel Dda University Health Board
Llanelli, United Kingdom
North Middlesex University Hospital - North Middlesex University Hospital NHS Trust
London, United Kingdom
The Whittington Hospital - Whittington Health NHS Trust
London, United Kingdom
UCL Hospital - University College London Hospitals NHS Foundation Trust
London, United Kingdom
Royal Free Hospital - Royal Free London NHS Foundation Trust
London, United Kingdom
Kings College Hospital - King's College Hospital NHS Foundation Trust
London, United Kingdom
The Royal Marsden NHS Foundation Trust
London, United Kingdom
Charing Cross Hospital -Imperial College Healthcare NHS Trust
London, United Kingdom
Luton and Dunstable Hospital -Bedfordshire Hospitals NHS Foundation Trust
Luton, United Kingdom
Wythenshawe Hospital - Manchester University Hospital NHS Foundation Trust
Manchester, United Kingdom
North Manchester General -Manchester University NHS Foundation Trust
Manchester, United Kingdom
Borders General Hospital -NHS Borders
Melrose, United Kingdom
Clatterbridge Cancer Centre - The Clatterbridge Cancer Centre NHS Foundation Trust
Metropolitan Borough of Wirral, United Kingdom
Clatterbridge Hospital - Wirral University Teaching Hospital NHS Foundation Trust
Metropolitan Borough of Wirral, United Kingdom
The James Cook University Hospital - South Tees Hospitals NHS Foundation Trust
Middlesbrough, United Kingdom
Milton Keynes Hospital - Milton Keynes University Hospital NHS Trust
Milton Keynes, United Kingdom
Royal Victoria Infirmary- Newcastle Upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, United Kingdom
North Tyneside General Hospital - Northumbria Healthcare NHS Foundation Trust
North Shields, United Kingdom
Churchill Hospital - Oxford University Hospitals NHS Foundation Trust
Oxford, United Kingdom
Royal Alexandra Hospital - NHS Greater Glasgow and Clyde
Paisley, United Kingdom
Derriford Hospital - University Hospitals Plymouth NHS Trust
Plymouth, United Kingdom
Queen Alexandra Hospital - Portsmouth Hospitals University NHS Trust
Portsmouth, United Kingdom
St Helen's Hospital - St Helens and Knowsley Teaching Hospitals NHS Trust
Prescot, United Kingdom
Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust
Preston, United Kingdom
East Surrey Hospital - Surrey & Sussex Healthcare NHS Trust
Redhill, United Kingdom
Rotherham General Hospital - The Rotherham NHS Foundation Trust
Rotherham, United Kingdom
Weston Park Hospital - Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, United Kingdom
St Alban's Hospital - West Hertfordshire Hospitals NHS Trust
St Albans, United Kingdom
Lister Hospital - East and North Hertfordshire NHS Foundation Trust
Stevenage, United Kingdom
University Hospital North Tees - North Tees and Hartlepool NHS Foundation Trust
Stockton-on-Tees, United Kingdom
Royal Stoke University Hospital - University Hospitals of North Midlands NHS Trust
Stoke-on-Trent, United Kingdom
Singleton hospital - Swansea Bay University Health Board
Swansea, United Kingdom
Musgrove park Hospital -Somerset NHS Foundation Trust
Taunton, United Kingdom
Croydon University Hospital - Croydon Health Services NHS Trust
Thornton Heath, United Kingdom
Royal Cornwall Hospital - Royal Cornwall Hospitals NHS Trust
Truro, United Kingdom
Hillingdon Hospital - The Hillingdon Hospitals NHS Foundation Trust
Uxbridge, United Kingdom
Pinderfields Hospital - Mid Yorkshire Hospitals NHS Trust
Wakefield, United Kingdom
Southend Hospital and Broomfield Hospital -Mid and South Essex NHS Foundation Trust
Westcliff-on-Sea, United Kingdom
Royal Albert Edward Infirmary - Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust
Wigan, United Kingdom
King Edward VII Hospital - Frimley Health NHS Foundation Trust
Windsor, United Kingdom
New Cross Hospital - The Royal Wolverhampton NHS Trust
Wolverhampton, United Kingdom
Worcestershire Royal Hospital - Worcestershire Acute Hospitals NHS Trust
Worcester, United Kingdom
Yeovil District Hospital -Yeovil District Hospital NHS Trust
Yeovil, United Kingdom
York Hospital - York and Scarborough Teaching Hospitals NHS Foundation Trust
York, United Kingdom