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MAintenance Therapy With Aromatase Inhibitor in Epithelial Ovarian Cancer (MATAO)
Sponsor: Swiss GO Trial Group
Summary
The purpose of this study is to evaluate the efficacy of addition of letrozole to the standard maintenance therapy in subjects following a primary diagnosis of Estrogen-receptor (ER) positive high and low grade epithelial ovarian cancer (including fallopian tube and primary peritoneal cancer) and subsequent primary treatment surgery and chemotherapy. Half of the participants will receive to the standard maintenance treatment, letrozole, whilst the other half receives placebo. The study's primary hypothesis is that the treatment with letrozole increases progression free survival in comparison to the maintenance standard treatment (superiority trial).
Official title: MAintenance Therapy With Aromatase Inhibitor in Epithelial Ovarian Cancer: a Randomized Double-blinded Placebo-controlled Multi-centre Phase III Trial (ENGOT-ov54/Swiss-GO-2/MATAO), Including LOGOS (Low Grade Ovarian Cancer Sub-study).
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
540
Start Date
2020-11-05
Completion Date
2032-07-01
Last Updated
2025-09-29
Healthy Volunteers
No
Conditions
Interventions
Letrozole 2.5mg
Aromatase inhibitor
Placebo
Placebo tablet of Femara
Locations (53)
Krankenhaus der Barmherzigen Brüder Graz
Graz, Austria
Medizinische Universität Graz
Graz, Austria
Medizinische Universität Innsbruck
Innsbruck, Austria
Landeskrankenhaus Hochsteiermark Leoben
Leoben, Austria
Ordensklinikum Linz Barmherzige Schwestern
Linz, Austria
Universitätsklinikum Salzburg
Salzburg, Austria
Medizinische Universität Wien
Vienna, Austria
Klinik Hietzing Wien
Vienna, Austria
Charité - Universitätsmedizin Berlin Campus Virchow Klinikum
Berlin, Germany
St. Elisabeth-Krankenhaus
Cologne, Germany
Donauisar Klinikum
Deggendorf, Germany
Universitätsklinikum Carl Gustav Carus Dresden
Dresden, Germany
Evangelisches Krankenhaus Düsseldorf
Düsseldorf, Germany
Universitätsklinikum Düsseldorf
Düsseldorf, Germany
Evangelische Kliniken Essen Mitte GmbH
Essen, Germany
Klinikum Esslingen
Esslingen am Neckar, Germany
University Hospital Freiburg
Freiburg im Breisgau, Germany
The University Medical Center Hamburg-Eppendorf
Hamburg, Germany
Agaplesion Diakonieklinikum Hamburg
Hamburg, Germany
Gynäkologisch-Onkologische Gemeinschaftspraxis Dres. med. C.Uleer/J.Y.Pourfard
Hildesheim, Germany
Klinikum Konstanz
Konstanz, Germany
Universitätsmedizin Mainz
Mainz, Germany
Universitätsklinikum Mannheim
Mannheim, Germany
University Hospital Münster
Münster, Germany
Studienzentrum Onkologie Ravensburg
Ravensburg, Germany
SL Klinikum Rosenheim
Rosenheim, Germany
Leopoldina Krankenhaus der Stadt Schweinfurt
Schweinfurt, Germany
Universitätsklinik Ulm
Ulm, Germany
Helios Dr. Horst Schmidt Kliniken Wiesbaden
Wiesbaden, Germany
AMO Wolfsburg / AMO MVZ GmbH
Wolfsburg, Germany
Helios Universitätsklinikum Wuppertal
Wuppertal, Germany
Kantonsspital Aarau AG
Aarau, Canton of Aargau, Switzerland
Universitätsspital Basel
Basel, Canton of Basel-City, Switzerland
Oncology Institute of Southern Switzerland (IOSI)-Ente Ospedaliero Cantonale (EOC)
Bellinzona, Canton Ticino, Switzerland
Centre Hospitalier du Valais Romand
Sion, Valais, Switzerland
Kantonsspital Baden AG
Baden, Switzerland
Basel Claraspital AG
Basel, Switzerland
Universitätsklinik für Medizinische Onkologie, Inselspital
Bern, Switzerland
Praxis im Frauenzentrum Lindenhofspital
Bern, Switzerland
Kantonspital Graubünden (KSGR),
Chur, Switzerland
Kantonsspital Frauenfeld
Frauenfeld, Switzerland
Hôpitaux Universitaires de Genève
Geneva, Switzerland
Frauenklinik Spital Grabs
Grabs, Switzerland
Universitätsspital Waadt/ CHUV
Lausanne, Switzerland
Kantonsspital Baselland
Liestal, Switzerland
Luzerner Kantonsspital
Lucerne, Switzerland
Tumorzentrum Hirslanden Klinik St. Anna
Lucerne, Switzerland
Kantonsspital Münsterlingen
Münsterlingen, Switzerland
Kantonsspital St. Gallen
Sankt Gallen, Switzerland
Kantonsspital Winterthur
Winterthur, Switzerland
Klinik für Onkologie und Hämatologie Hirslanden Zürich AG
Zurich, Switzerland
Stadtspital Triemli
Zurich, Switzerland
Unispital Zürich
Zurich, Switzerland