Clinical Research Directory

Inclusion Criteria: * Ability to understand and give informed consent * Males and Females 18-64 years of age * DSM-5 diagnosis of OUD with heroin as the primary drug of choice * Stabilized on methadone or other form of MAT. Inclusion criteria for healthy controls: \- The same as inclusion criteria 1-2 above; dependence on nicotine or caffeine is non-exclusionary. Exclusion Criteria: * DSM-5 diagnosis for schizophrenia or developmental disorder (e.g., autism) * Head trauma with loss of consciousness * History of neurological disease of central origin including seizures * Cardiovascular disease including high blood pressure and/or other medical conditions, including metabolic, endocrinological,oncological or autoimmune diseases, and infectious diseases common in iOUD including Hepatitis B and C or HIV/AIDS * Metal implants or other MR contraindications Exclusion criteria for healthy control subjects: \- The same, except history of any drug use disorder is prohibitive.