Clinical Research Directory
Browse clinical research sites, groups, and studies.
Measuring the Healthy Pediatric Inflammatory Response to Vaccination.
Sponsor: Mayo Clinic
Summary
The purpose of this research is to understand the normal healthy response to immunological challenge by measuring circulating cytokine and chemokine levels before and after vaccinations in healthy children. These data will define a range of normal responses that can be used to help us understand pathogenic mechanisms in children who do not respond normally to infections. In addition, this study will test the hypothesis that genetic polymorphisms in the interleukin-1 receptor antagonist gene are associated with differential inflammatory responses across the healthy spectrum.
Official title: Establishing the Dynamic Range of Healthy Pediatric Inflammatory Responses to Vaccinations and Identifying the Role of IL1RN Polymorphisms in Controlling This Response.
Key Details
Gender
All
Age Range
4 Months - 21 Years
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2019-08-16
Completion Date
2028-12
Last Updated
2026-01-22
Healthy Volunteers
Yes
Conditions
Interventions
Blood Collection
Blood draw
Locations (1)
Mayo Clinic
Rochester, Minnesota, United States