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Renal Physiology During Continuous Renal Replacement Therapy
Sponsor: Sahlgrenska University Hospital
Summary
Approximately 50% of patients in the intensive care unit (ICU) develop acute kidney injury (AKI) and more than 10% need dialysis. There is no treatment for AKI. Care is aiming for optimization of circulation and blood flow to the kidneys and avoiding nephrotoxic agents. There is conflicting data concerning whether early or late dialysis is harmful for the kidneys. No one has examined the physiological changes in the kidney when starting dialysis and which blood pressure that leads to most optimal physiological conditions for the kidneys during dialysis. In this descriptive study of 20 ICU patients suffering from AKI we aim to investigate renal physiology when starting continuous renal replacement therapy (CRRT) and also at different target blood pressures using retrograde renal vein thermodilution technique. In parallel we will also investigate and validate this invasive method with contrast enhanced ultrasound of the kidneys.
Official title: Impact of Continuous Renal Replacement Therapy on Renal Oxygenation, Blood Flow and Function
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2020-11-20
Completion Date
2025-12-31
Last Updated
2024-04-18
Healthy Volunteers
No
Conditions
Interventions
Starting at high or low blood pressure
Using norepinephrine, patients will receive high or low blood pressure to start with and after measurements cross to receive the other blood pressure target
Locations (1)
Sahlgrenska University Hospital
Gothenburg, Sweden