Clinical Research Directory

Inclusion Criteria: * Able to provide informed consent * Cannabis users in Study A must have smoked or vaped cannabis at least once since January 1st 2014 with no negative effects but NOT used in the past three months * Cannabis users in Study B must have been a regular (at least weekly) user for at least a year * Non-users in Study B cannot have used any cannabis in the previous year * Weight stable (\<5 pound fluctuation in the past six months) * Planning to remain in the Boulder-Denver area for the next month * Fasting blood glucose greater than or equal to 55 mg/dl and less than or equal to 126 mg/dl * Cannabis users in Study A must endorse knowledge of the procedure(s) for smoking or vaping cannabis Exclusion Criteria: * Known auto-immune disease * Report of other drug use (cocaine, opiates, methamphetamine) in the past 90 days or fail urine screen for any of these drugs * Daily tobacco (cigarette, E-cigs, smokeless) user, given the impact of tobacco smoking on insulin function * Blood alcohol level greater than 0 at screening * Current use of medications for glucose lowering, immunosuppression, or anti-inflammation * Acute illness * Current use of psychotropic medications * Current diagnosis of diabetes * Heavy drinking as defined by an Alcohol Use Disorders Test (AUDIT) * Females can not be pregnant or trying to become pregnant * Females can not be nursing mothers * Have donated blood in the 8 weeks before the study or intend to donate blood in the 8 weeks after the study.