Clinical Research Directory

Inclusion Criteria: 1. Adult patients (age ≥ 18 years) with steroid refractory acute GvHD grades II-IV after allo-HSCT. 2. Signed written study informed consent once SR-aGvHD is confirmed. Exclusion Criteria: 1. Presence of an active uncontrolled infection including significant bacterial, fungal, viral or parasitic infection requiring treatment. 2. Has received systemic treatment for aGvHD apart from steroids. 3. Clinical presentation resembling de novo chronic GvHD or GvHD overlap syndrome. 4. Pregnant or lactating women. 5. Significant respiratory disease. 6. Presence of severely impaired renal function 7. Any corticosteroid therapy for indications other than aGvHD 8. Previous participation in a study of any investigational treatment agent within 30 days 9. Known human immunodeficiency virus infection (HIV). 10. Patients suffering on active tuberculosis or viral hepatitis 11. Significant respiratory disease 12. Presence of severely impaired renal or liver function 13. History of progressive multifocal leuko-encephalopathy 14. Patients with coagulopathy 15. History of severe chronic history of heart disease 16. Any condition that would, in the Investigator's judgment, interfere with full participation in the study.