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Causal Mechanisms in Adolescent Arterial Stiffness
Sponsor: Baylor College of Medicine
Summary
Hardening of the blood vessels, called arterial stiffness, is a risk factor for future heart disease and its causes are unclear. The proposed study will 1) randomly assign adolescents at high risk of stiffening blood vessels to take a protein supplement called carnitine and study its effects on arterial stiffening and 2) study carnitine related genes for their effect on arterial stiffening. The study will definitively establish a role for carnitine action as a cause of stiffening blood vessels and signal a way to treat or prevent stiffening.
Key Details
Gender
All
Age Range
11 Years - 21 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2020-02-01
Completion Date
2026-08-31
Last Updated
2025-12-10
Healthy Volunteers
No
Conditions
Interventions
CS+
Oral carnitine supplementation
CS-
Placebo
Locations (1)
Texas Children's Hospital
Houston, Texas, United States