Clinical Research Directory

Inclusion Criteria: * Patients and volunteers: * Adults (age ≥18 years), male or female, * For female in age, efficient contraception will be required and a negative pregnancy test will be required, * Signed informed consent form will required for each included subject after having read the information note, * Affiliated to the national social security system, * Patients: .Patients diagnosed to have HCM secondary to sarcomeric mutation or to Fabry disease, symptomatic (dyspnea on exertion and/or chest pains during exercise), * Healthy volunteers: * Subjects without known cardiac disease, * No smokers. Exclusion Criteria: * Patients and volunteers: * No cardiac pathology reducing life expectancy to less than 12 months (cancer), * Unbalanced arterial hypertension (systolic \>160 mmHg and/or diastolic \>120 mmHg), * Pregnancy or breastfeeding, * Major obesity \> 140 kg, * Impossibility or refusal to give or sign the consent form, * Subject in period of exclusion relative to an other protocol, * Subject deprived of liberty by judicial or administrative decision, * Major protected by the Law * Patients: * Atrial fibrillation at the time of inclusion * Valvulopathy with severity greater than moderate.