Clinical Research Directory
Browse clinical research sites, groups, and studies.
Personalized Swiss Sepsis Study
Sponsor: University Hospital, Basel, Switzerland
Summary
This multi-center study is to focus on patients with sepsis in Intensive Care Units (ICUs) in order to better understand the complex host-pathogen interaction and clinical heterogeneity associated with sepsis. Understanding this heterogeneity may allow the development of novel diagnostic approaches. Data from patients will be analyzed using state-of-the art analytical algorithms for biomarker discovery including machine learning and multidimensional mathematical modelling to explore the large datasets generated. In order to discover digital biomarkers for the study endpoints a case-control study design will be used to compare data patterns from patients with sepsis (cases) and those without sepsis (controls).
Official title: Personalized Swiss Sepsis Study: With Machine Learning and Computational Modelling Towards Personalized Sepsis Management - Discovery of Digital Biomarkers
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
17500
Start Date
2019-11-15
Completion Date
2025-12
Last Updated
2025-03-05
Healthy Volunteers
No
Conditions
Interventions
compare data patterns by data-driven algorithms to determine sepsis
compare data patterns by data-driven algorithms including machine learning and multi-dimensional modelling to reliably determine sepsis
compare data patterns by data-driven algorithms to predict sepsis-related mortality
compare data patterns by data-driven algorithms including machine learning and multi-dimensional modelling to to predict sepsis-related mortality
Locations (16)
Clinical Microbiology, University Hospital Basel
Basel, Switzerland
Infectious Diseases and Hospital Epidemiology, University Hospital Basel
Basel, Switzerland
Medical Intensive Care Unit; University Hospital Basel
Basel, Switzerland
Surgical Intensive Care Unit, University Hospital Basel
Basel, Switzerland
Institute for Infectious Diseases, University of Bern
Bern, Switzerland
Division Infectious Diseases, University Hospital Bern
Bern, Switzerland
Intensive Care Medicine, University Hospital Bern
Bern, Switzerland
Division Bacteriology Laboratory, University Hospital Geneva
Geneva, Switzerland
Division Infectious Diseases, University Hospital Geneva
Geneva, Switzerland
Intensive Care Medicine, University Hospital Geneva
Geneva, Switzerland
Division Intensive Care Medicine, University Hospital Lausanne
Lausanne, Switzerland
Institute of Microbiology, University Hospital Lausanne
Lausanne, Switzerland
Service Infectious Diseases, University Hospital Lausanne
Lausanne, Switzerland
Institute for Medical Microbiology, University Hospital Zurich
Zurich, Switzerland
Division Infectious Diseases, University Hospital Zurich
Zurich, Switzerland
Institute for Intensive Medicine, University Hospital Zurich
Zurich, Switzerland