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Carbon Dioxide (CO2) Chemosensitivity and SUDEP
Sponsor: University of Iowa
Summary
The purpose of this research study is to better understand what causes Sudden Unexpected Death in Epilepsy (SUDEP). This study will enroll subjects from the University of Iowa Hospitals and Clinics (UIHC) Epilepsy Monitoring Unit (EMU) and Epilepsy Clinics. The investigators will analyze the effects of seizures on breathing, on the cardiovascular system, and on arousal. The investigators are studying these effects because some cases of SUDEP might be due, in part, to an inability to wake up or sense elevated carbon dioxide (CO2) levels when breathing is impaired. Subjects will be followed for ten years after enrollment to monitor their health.
Official title: The Role of Central CO2 Chemosensitivity in Postictal Respiratory Depression and SUDEP
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
335
Start Date
2019-12-12
Completion Date
2029-10-01
Last Updated
2026-03-09
Healthy Volunteers
No
Interventions
6% Carbon dioxide/50% oxygen/balance nitrogen mixture
In the hypercapnic ventilatory response (HCVR) test, the subject will rebreathe a gas mixture that has 6% carbon dioxide and 50% oxygen. This test has been performed for decades for research and clinical purposes. The effects of carbon dioxide inhalation are short lived and do not cause long term consequences. the hypercapnic ventilatory response (HCVR), we will have you
Locations (1)
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States