Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Clinical Trial Utilizing Dantrolene in Patients With Ventricular Arrhythmias.
Sponsor: Vanderbilt University Medical Center
Summary
This is a randomized, placebo-controlled trial of Dantrolene (N= 84 participants) to demonstrate the feasibility of using intravenous (IV) dantrolene to study the effect of RyR2 inhibition on cardiac electrophysiology, hemodynamics, and ventricular arrhythmia inducibility in patients with structural heart disease referred for Ventricular Tachycardia (VT) ablation. The investigators will also explore the pharmacokinetic/pharmacodynamic relationship of IV dantrolene and its short-term effect on specific cardiac electrophysiologic and hemodynamic parameters.
Official title: A Randomized Controlled Trial of RyR2 Inhibition With Dantrolene and Susceptibility to Ventricular Arrhythmias in Patients With Structural Heart Disease.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
68
Start Date
2020-08-21
Completion Date
2025-08-29
Last Updated
2026-10-08
Healthy Volunteers
No
Conditions
Interventions
Dantrolene/Ryanodex
muscle relaxant
Placebo
Controlled placebo of saline administered Intravenous; 1 mg/kg IV over 3 minutes, one time dose
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States