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Comparison of Esophagectomy and Chemoradiation for Patients With cN0-pT1b Stage Esophageal Squamous Cell Carcinoma
Sponsor: Shanghai Chest Hospital
Summary
The ad-ESD trial is phase III randomized trial to compare adjuvant esophagectomy and chemoradiation for patients with clinical stage N0 and pathological stage T1b squamous cell carcinoma (after endoscopic submucosal dissection).
Official title: Adjuvant Esophagectomy Versus Chemoradiation for Patients With Clinical Stage N0 and Pathological Stage T1b (After Endoscopic Submucosal Dissection, ESD) Esophageal Squamous Cell Carcinoma (Ad-ESD Trial): a Multicentric, Open Label, Randomized Trial
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
176
Start Date
2019-09-01
Completion Date
2027-12-01
Last Updated
2019-10-22
Healthy Volunteers
No
Conditions
Interventions
esophagectomy
esophagectomy with at least two-field (thoracic-abdominal) lymphadenectomy
chemoradiation
concurrent chemotherapy and radiotherapy
active surveillance
No further adjuvant therapy
Locations (6)
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
Changhai Hospital, The Second Military Medical University
Shanghai, China
Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine
Shanghai, China
Shanghai Chest Hospital, Shanghai Jiao Tong University
Shanghai, China
Zhongshan Hospital, Fudan University
Shanghai, China
Tianjin Medical University Cancer Institute and Hospital
Tianjin, China