Identification of Genetic Causes of Calcific Aortic Valve Disease

ACTIVE NOT RECRUITING

NCT04149600

Sponsor: Beth Israel Deaconess Medical Center

Summary

This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.

Key Details

Gender

All

Age Range

20 Years - Any

Study Type

OBSERVATIONAL

Enrollment

1000

Start Date

2018-09-25

Completion Date

2027-06-30

Last Updated

2025-05-30

Healthy Volunteers

Yes

Conditions

Calcific Aortic Stenosis Calcific Aortic Stenosis - Bicuspid Valve Aortic Valve Disease Aortic Valve Calcification Aortic Diseases Aortic Aneurysm Aortic Valve Cusp Abnormality Aortic Valve Disease Mixed Aortic Valve Insufficiency

Interventions

PROCEDURE

Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.

Adult patients undergoing aortic valve replacement (AVR) and/or aortic resection will be enrolled.

Locations (1)

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

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