Clinical Research Directory

Inclusion Criteria: * All patients with two to eight bouts of migraine without an aura per month * All patient aged (≥) 18 to (≤) 60 years old * All patients who have not had a bout of migraine in the last 24 hours * All patients who have given free informed consent and have signed the consent form. * All patients who are affiliated to or beneficiaries of a health insurance scheme * All patients available for a two-month follow-up Exclusion Criteria: * All patients with migraine which is secondary to a neurological, neuropsychiatric, or vascular disorder * All patients suffering from diabetes * All patients with a past history of alcohol or drug abuse * All patients with contraindications for an MRI scan * All patients on antidepressants or Botox. * All patients already taking part in Category 1 research involving the human person * All patients on an exclusion period determined by another study * All patients placed under judicial protection, guardianship, or supervision * All patients for whom it is impossible to give the subject clear information * All patients who are pregnant, about to give birth or breastfeeding * All patient who have received botulinum toxin in the past year * All patient who have undergone antidepressant treatment in the last 2 months * All patient who have started a background migraine treatment for less than 3 months * All patient who have more than 14 migraine days per month