Clinical Research Directory

Inclusion criteria * Does the patient have maximum wall thickness \>13mm by any imaging technique? i) If so, does the patient have a first degree relative (sibling, parent, child) with a formal diagnosis of HCM -AND- ii) Does the patient have any of the following: Does the patient have any of the following: abnormal Doppler myocardial imaging or strain, incomplete systolic anterior motion, elongation of mitral valve leaflets and abnormal papillary muscles, abnormal ECG? -OR- * Does the patient have maximum wall thickness 15mm or more by any imaging technique? * Is the patient male or female 18-100years of age? * High or intermediate risk for sudden cardiac death from HCM based on the ESC risk calculator predicting \>4% risk over 5 years by specialist inherited cardiac disease clinic. This would use the online SCD-risk calculator Exclusion criteria * Patients with previous cardiac arrest * Patients with haemodynamically unstable VT needing medical attention. * Evidence of one of the following conditions causing secondary hypertrophy: a. Hypertension \>200/100; Severe aortic stenosis; Anderson-Fabry disease; Myocarditis; Congenital heart disease; TTR-related amyloidosis; Myotonic dystrophy; Mitochondrial disease, Noonan syndrome, LEOPARD syndrome, Costello syndrome, Danon disease, Friedreich's ataxia, Glycogen storage disease, FHLI mutation, PRKAG2 mutations * Patients with previous appropriate therapy from an ICD. * Patients under the age of 18 years * Patients who are not safe to discontinue Beta blockers * Patients unable to exercise due to musculoskeletal problems * Patients with skin allergies to ECG gel/electrodes. * Life expectancy shorter than the duration of the trial. * Pregnant or planning pregnancy at the time of CT scan. * Patients unable to consent to the study protocol or provide contact details for follow up. * Patients currently participating in an interventional medical or device trial.