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Live Attenuated Influenza Vaccine as a Nasal Model for Influenza Infection
Sponsor: University of Alabama at Birmingham
Summary
The purpose of this study is to develop a nasal model for influenza infection using the live attenuated influenza vaccine (LAIV). The investigators will administer LAIV to healthy adult volunteers in order to simulate influenza infection, and obtain nasal specimens to measure influenza virus and inflammatory/immune responses. In a subset of participants, cystic fibrosis transmembrane conductance regulator (CFTR) function will also be evaluated via measurement of nasal potential difference (NPD)
Key Details
Gender
All
Age Range
18 Years - 49 Years
Study Type
INTERVENTIONAL
Enrollment
33
Start Date
2020-09-01
Completion Date
2026-01-22
Last Updated
2026-09-25
Healthy Volunteers
Yes
Conditions
Interventions
Flumist Quadrivalent Nasal Product
FLUMIST QUADRIVALENT 0.2 mL dose supplied in a single-dose pre-filled intranasal sprayer
Locations (1)
UAB Lung Health Center
Birmingham, Alabama, United States