Clinical Research Directory

Inclusion Criteria: * Aged 18 years old or over * New diagnosis of a malignant glioma (HGG) either by a biopsy or craniotomy * KPS of at least 70 * Being able to fill out quality of life questionnaire Exclusion Criteria: * Other major diseases of the central nervous system, including history of prior brain tumors, Alzheimer's disease, Parkinson's disease, demyelinating disease, inflammatory brain or vascular disease, traumatic encephalopathy, or idiopathic intracranial hypertension, anxiety/depression. * Pre-existing neurological disability, unable to read or write * Severe comorbidities likely to result in patient dying within 3 months * Prior history of head/neck radiation therapy * Other active cancer or history of other cancer diagnosed within 5 year. * Inability to safely tolerate the 1500 ml- 2000ml fluid load (po water) associated with study medication\* * Pregnancy or nursing. * Treatment with another investigational drug within the last 30 days that may interfere with this study's medications\* * Hypersensitivity to Temozolomide and or it's active agent- Dacarbazine