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Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.
Sponsor: Morten H. Bestle
Summary
This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit. Half of the patients will receive furosemide and the other half placebo. The treatment will continue until the excess fluid is excreted.
Official title: Goal Directed Fluid Removal With Furosemide in Intensive Care Patients With Fluid Overload - A Randomised, Blinded, Placebo-controlled Trial (GODIF).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1000
Start Date
2020-08-17
Completion Date
2028-03-15
Last Updated
2025-02-06
Healthy Volunteers
No
Conditions
Interventions
Furosemide
Furosemide 10 mg/ml for injection/infusion
Isotonic saline
Isotonic saline used as placebo (injection/infusion)
Locations (24)
Department of Intensive Care, Liverpool Hospital
Sydney, Australia
Department of Intensive Care, Sygehus Sønderjylland Aabenraa
Aabenraa, Denmark
Departmen of Intensive Care
Aalborg, Denmark
Department of Intensive Care, Aarhus University Hospital
Aarhus, Denmark
Department of Intensive Care, Rigshospitalet
Copenhagen, Denmark
Departement of Intensive Care, Gentofte Hospital
Gentofte Municipality, Denmark
Department of Intensive Care, Herlev Hospital
Herlev, Denmark
Department of Intensive Care, Regionshospital Gødstrup
Herning, Denmark
Department of Intensive Care, Nordsjællands hospital
Hillerød, Denmark
Department of Intensive Care, Regionshospital Nordjylland Hjørring
Hjørring, Denmark
Department of Intensive Care
Kolding, Denmark
Department of Intensive Care, Zealand University hospital
Køge, Denmark
Department of Intensive Care
Odense, Denmark
Department of Intensive Care, Regionshospitalet Randers
Randers, Denmark
Department of Intensive Care, University Hospital Zealand, Roskilde
Roskilde, Denmark
Department of Intensive Care
Vejle, Denmark
Regionshospitalet Viborg
Viborg, Denmark
Department of Intensive Care, Tampere University Hospital
Tampere, Finland
Department of Intensive Care
Turku, Finland
Department of Intensive Care, Landspitali National University Hospital of Iceland
Reykjavik, Iceland
Department of Critical Care, University Medical Center Groningen
Groningen, Netherlands
Department of Intensive Care, Ålesund Sjukehus
Ålesund, Norway
Department of Intensive Care, Stavanger University Hospital
Stavanger, Norway
Department of Intensive Care, Inselspital
Bern, Switzerland