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RECRUITING

NCT04185935

Molecular Genetics Studies of Cancer Patients and Their Relatives

Sponsor: City of Hope Medical Center

View on ClinicalTrials.gov

Summary

This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.

Key Details

Gender

All

Age Range

Any - Any

Study Type

OBSERVATIONAL

Enrollment

999999

Start Date

1997-04-18

Completion Date

2033-08-18

Last Updated

2025-06-25

Healthy Volunteers

Yes

Conditions

Malignant Neoplasm

Interventions

OTHER

Biospecimen Collection

Provide a sample of blood, a saliva sample, a sample of eyebrow plucks, a sample of urine, and/or stored tumor or healthy tissue

OTHER

Questionnaire Administration

Ancillary studies

Inclusion Criteria: * Individuals must have a personal history of cancer and/or a family history of cancer suggestive of the presence of an inherited predisposition. This inherited predisposition might manifest as: * Young age cancer diagnosis * Multiple primary neoplasms in affected member * The presence of rare tumor types in the family * Congenital malformations * Any other family clustering of cancer * Any other cancer-predisposing genetic diseases/conditions * Individuals may also be eligible by participation in the City of Hope Cancer Screening \& Prevention Program Network (CSPPN) clinical service or on the basis of membership in a group known or suspected to have an increased risk of carrying a genetic alteration or of sustaining a particular exposure that would place that at increased risk of cancer. (Examples would include members of occupational cohorts like asbestos workers, individuals with multiple dysplastic nevi in the absence of a family history of cancer, and individuals descended from a particular tribe in the American Southwest who have an increased incidence of a rare genetic alteration associated with an increased risk of a specific cancer.) * Individuals and families may be referred to us in a number of different ways. After initial contact is made with a individual or family by family studies personnel; an individual within the bloodline will be identified as the historian. There may be more than one historian within a family * At least one historian must be wiling to provide information or access as needed to contact appropriate family members for documentation of cancer and for consent. An individual is considered to be eligible to participate if they criteria; contact with relatives is not always indicated * Individuals who are under 18 are eligible for study if they meet the criteria. Consent for participation must be given by a legal guardian or parent * Deceased patients may be included in the study. Public records, such as death certificates, can be used to confirm information from individuals or family members. If medical records are needed, consent for these records will be obtained from the deceased's next of kin. Next of kin refers to the following hierarchy of relatives; spouse, offspring, parents, and siblings. (Any further use of next of kin in this protocol should relate back to this hierarchy.) Archived tissue samples, such as pathology blocks or snap frozen tumor from a pathology department tumor bank (discard specimens) may be used for genetic research Exclusion Criteria: * A family may be ineligible for study if the historian will not allow access to anyone within the family and thus, the accuracy of the family history cannot be established

Locations (42)

Valleywise Comprehensive Health Center - Phoenix

Phoenix, Arizona, United States

John Muir Medical Center-Concord Campus

Concord, California, United States

City of Hope Medical Center

Duarte, California, United States

Saint Jude Medical Center

Fullerton, California, United States

Saddleback Memorial Medical Center

Laguna Hills, California, United States

USC / Norris Comprehensive Cancer Center

Los Angeles, California, United States

Saint Joseph Hospital - Orange

Orange, California, United States

Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, United States

Cancer Center of Santa Barbara

Santa Barbara, California, United States

Lynn Regional Cancer Center - West

Boca Raton, Florida, United States

Holy Cross Hospital

Fort Lauderdale, Florida, United States

Kootenai Cancer Center

Post Falls, Idaho, United States

John H Stroger Jr Hospital of Cook County

Chicago, Illinois, United States

Rush University Medical Center

Chicago, Illinois, United States

Mercy Hospital

Cedar Rapids, Iowa, United States

Suburban Hospital

Bethesda, Maryland, United States

Frederick Oncology Hematology Associates

Frederick, Maryland, United States

Steward Saint Elizabeth's Medical Center

Brighton, Massachusetts, United States

Hunterdon Medical Center

Flemington, New Jersey, United States

Lovelace Medical Center-Downtown

Albuquerque, New Mexico, United States

New Mexico Oncology Hematology Consultants

Albuquerque, New Mexico, United States

Presbyterian Kaseman Hospital

Albuquerque, New Mexico, United States

Mount Kisco Medical Group at Northern Westchester Hospital

Mount Kisco, New York, United States

Health Quest Medical Practice PC-Cardio Thoracic

Poughkeepsie, New York, United States

Aultman Health Foundation

Canton, Ohio, United States

Saint Charles Health System

Bend, Oregon, United States

Paoli Memorial Hospital

Paoli, Pennsylvania, United States

Reading Hospital

West Reading, Pennsylvania, United States

The Don and Sybil Harrington Cancer Center

Amarillo, Texas, United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, United States

Doctor's Hospital of Laredo

Laredo, Texas, United States

Covenant Medical Center

Lubbock, Texas, United States

Saint Agnes Hospital/Agnesian Cancer Center

Fond du Lac, Wisconsin, United States

ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, United States

Cheyenne Regional Medical Center-West

Cheyenne, Wyoming, United States

Clinica del Country

Bogotá, Cundinamarca, Colombia

Instituto de Cancerologia Las Americas

Medellín, Colombia

University of Guadalajara

Guadalajara, Jalisco, Mexico

Salvador Zubiran National Institute of Health Sciences and Nutrition

Mexico City, Tlalpan, Mexico

Monterrey Institute of Technology-TecSalud

Nuevo León, Mexico

Instituto Nacional de Enfermedades Neoplasicas

Lima, Peru

University of Puerto Rico

San Juan, Puerto Rico

Clinical Research Directory

Molecular Genetics Studies of Cancer Patients and Their Relatives

Summary

Key Details

Conditions

Interventions

Eligibility Criteria

Locations (42)