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RECRUITING

NCT04188535

Serial MRI Scans During Radiation Therapy

Sponsor: Dana-Farber Cancer Institute

View on ClinicalTrials.gov

Summary

This is a phase 1 study to determine the feasibility and utility of using serial magnetic resonance imaging (MRI) to assess treatment response during and after radiation therapy (standard of care cancer treatment) for participants with advanced esophageal cancer, glioblastoma, prostate cancer, vulvar cancer or pediatric glioma. The research study procedures include three MRI scans (one before, one during, and one after standard of care cancer radiation therapy) for participants with advanced esophageal cancer, glioblastoma, prostate cancer, vulvar cancer or pediatric glioma. The research study procedures include: * Screening for eligibility * Three MRI scans

Official title: RELAY: Repeated Magnetic Resonance Imaging Examinations to Analyze and Assess Your Cancer: A Prospective Study on the Use of Serial Magnetic Resonance Imaging in the Assessment of Changes During Treatment With Radiation Therapy

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

149

Start Date

2020-01-15

Completion Date

2030-07-31

Last Updated

2025-08-26

Healthy Volunteers

Conditions

Glioblastoma Esophageal Cancer Radiotherapy Magnetic Resonance Imaging MRI Prostate Cancer Vulvar Cancer Pediatric Glioblastoma Multiforme

Interventions

DIAGNOSTIC_TEST

MRI IMAGING

Imaging with MRI will be performed as per disease site standards.

Inclusion Criteria: * Participants must have a confirmed malignancy requiring radiation therapy. * Age: 18 years or older except where otherwise specified in subprotocol. * ECOG performance status ≤2 (Karnofsky ≥60%) * Ability to understand and the willingness to sign a written informed consent document. * Any further criteria listed in the specific disease site subprotocol. * (Esophageal cohort) Patients must be considered appropriate candidates for neoadjuvant chemoradiation therapy followed by esophagectomy. Patients must have an endoscopic ultrasound done or scheduled to be done at the baseline visit. * (Glioblastoma cohort) Patients with a histologically confirmed newly diagnosed intracranial glioblastoma or gliosarcoma who will be undergoing radiation therapy as part of clinical care. * (Prostate cohort) Patients with localized prostate cancer who are planning to receive androgen deprivation therapy and definitive radiation therapy. * (Vulvar cohort) Patients with biopsy-proven locally advanced vulvar cancer for which definitive radiotherapy is planned. * (Pediatric glioma cohort) Patients age 18 or under (patients 18-30 years old are also eligible if the physician determines that based on genetics, the tumor biology is consistent with pediatric high grade glioma). Patients with a histologically confirmed newly diagnosed high-grade glioma (WHO grade III or IV) who will be undergoing radiation therapy as part of clinical care. Patients with DIPG are only eligible if biopsy-confirmed high grade DIPG is present. Ability to understand and/or willingness of their parent or legally authorized representative to sign a written informed consent document. Exclusion Criteria: * Disease-specific exclusion criteria will be specified in a subprotocol. * For MRI involving contrast, history of allergic reactions attributed to gadolinium-based IV contrast. If patient will not receive contrast, this is not applicable and kidney function will not affect eligibility. * Inability to undergo magnetic resonance imaging (MRI).

Locations (2)

Brigham and Women Hospital

Boston, Massachusetts, United States

Dana Farber Cancer Institute