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Return of Genomic Results and Aggregate Penetrance in Population-Based Cohorts
Sponsor: Brigham and Women's Hospital
Summary
The PopSeq Project is a prospective cohort study that will develop and implement a genomic return of results (gRoR) process in the Framingham Heart Study (FHS) and Jackson Heart Study (JHS) cohorts and explore associated medical, behavioral, and economic outcomes. The study will interpret the genomic sequences of JHS/FHS participants previously sequenced by TOPMed who have consented to genomic return of results and/or genetic testing. We will develop and apply new methods for scalable screening/ classification of genomic variants and will explore genomic penetrance by phenotyping a subset of participants in the FHS and JHS.
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
7603
Start Date
2021-06-09
Completion Date
2025-05-30
Last Updated
2026-08-03
Healthy Volunteers
No
Interventions
Genomic Sequencing
Whole Genome Sequencing and reporting of actionable genomic results for genes included on the ACMG secondary findings list.
Locations (2)
Framingham Heart Study
Framingham, Massachusetts, United States
Jackson Heart Study
Jackson, Mississippi, United States