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Optimization of a Non-invasive Electrophysiological Method for Studying the Functionality of Auditory Nerve Fibers
Sponsor: University Hospital, Clermont-Ferrand
Summary
Acoustic overexposure can induced temporary or hearing loss. Usually hearing loss is associated with cochlear cell damages. Recently, a new pathological entity was described and called "hidden hearing loss". In animal model, the histopathology revealed a selective reduction in the number of auditory fibers, resulting in a decrease in the amplitude of wave I of the auditory brainstem response. Electrocochleography (Ecog) is a method for recording the electrical potentials of the cochlea (e.g. wave I). In clinical routine, Ecog is performed invasively with sedation or local anesthesia. Actually, a non invasive approach could be perform but it seems necessary to optimize this method and to define reference values in healthy volunteers.
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
430
Start Date
2019-04-29
Completion Date
2026-05
Last Updated
2023-08-09
Healthy Volunteers
Yes
Interventions
Electrocochleography, electrophysiology thet for analyse the wave I generated by the auditory pathways
Electrocochleography is a technique that analyses the functionality of inner ear.
Locations (1)
Chu Clermont Ferrand
Clermont-Ferrand, France