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RECRUITING
NCT04199026
NA

Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma

Sponsor: M.D. Anderson Cancer Center

View on ClinicalTrials.gov

Summary

This early phase I trial studies the side effects of implanting and removing a microdevice in patients with sarcomas that have spread to other places in the body (metastatic) or have come back (recurrent). Microdevices are rice-sized devices that are implanted into tumor tissue and are loaded with 10 different drugs that are delivered at very small doses, or "microdoses," which may only affect a very small, local area inside the tumor. The purpose of this study is to determine which drugs delivered in the microdevice affect tumor tissue in patients with sarcomas.

Official title: Pilot Trial of an Implantable Microdevice for In Vivo Drug Sensitivity Testing in Patients With Sarcomas

Key Details

Gender

All

Age Range

10 Years - Any

Study Type

INTERVENTIONAL

Enrollment

20

Start Date

2025-02-25

Completion Date

2028-12-31

Last Updated

2026-02-19

Healthy Volunteers

No

Interventions

DRUG

Doxorubicin

Given via microdevice

DRUG

Doxorubicin Hydrochloride

Given via microdevice

DEVICE

Drug Delivery Microdevice

Undergo percutaneous implantation of drug delivery microdevice

DRUG

Everolimus

Given via microdevice

BIOLOGICAL

Ganitumab

Given via microdevice

DRUG

Ifosfamide

Given via microdevice

DRUG

Irinotecan

Given via microdevice

DRUG

Pazopanib

Given via microdevice

DRUG

Polyethylene Glycol

Given via microdevice

DRUG

Temozolomide

Given via microdevice

DRUG

Temsirolimus

Given via microdevice

PROCEDURE

Therapeutic Conventional Surgery

Undergo standard of care surgery

DRUG

Vincristine

Given via microdevice

Locations (1)

M D Anderson Cancer Center

Houston, Texas, United States