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Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma
Sponsor: M.D. Anderson Cancer Center
Summary
This early phase I trial studies the side effects of implanting and removing a microdevice in patients with sarcomas that have spread to other places in the body (metastatic) or have come back (recurrent). Microdevices are rice-sized devices that are implanted into tumor tissue and are loaded with 10 different drugs that are delivered at very small doses, or "microdoses," which may only affect a very small, local area inside the tumor. The purpose of this study is to determine which drugs delivered in the microdevice affect tumor tissue in patients with sarcomas.
Official title: Pilot Trial of an Implantable Microdevice for In Vivo Drug Sensitivity Testing in Patients With Sarcomas
Key Details
Gender
All
Age Range
10 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-02-25
Completion Date
2028-12-31
Last Updated
2026-02-19
Healthy Volunteers
No
Interventions
Doxorubicin
Given via microdevice
Doxorubicin Hydrochloride
Given via microdevice
Drug Delivery Microdevice
Undergo percutaneous implantation of drug delivery microdevice
Everolimus
Given via microdevice
Ganitumab
Given via microdevice
Ifosfamide
Given via microdevice
Irinotecan
Given via microdevice
Pazopanib
Given via microdevice
Polyethylene Glycol
Given via microdevice
Temozolomide
Given via microdevice
Temsirolimus
Given via microdevice
Therapeutic Conventional Surgery
Undergo standard of care surgery
Vincristine
Given via microdevice
Locations (1)
M D Anderson Cancer Center
Houston, Texas, United States