Clinical Research Directory

Inclusion Criteria: * Adult patient aged ≥18 and ≤ 71 years old * BMI ≥ 40 or BMI ≥ 35 in association with one of the following comorbidities: hypertension, type 2 diabetes, obstructive sleep apnea * Relative contraindication to bariatric surgery * Able to sign informed consent. Exclusion Criteria: General * Impossible or unwilling to attend follow-up visits. * Weight \> 250kg (weight limit of angiography table) * Confirmed allergy to intravenous contrast agents. * Pregnancy, breast feeding or willingness to conceive during the following year * Impossible to maintain dorsal decubitus during intervention * Life expectancy \< 1 year * Current enrollment in another clinical trial * Arterial anatomy rendering embolization very difficult or impossible (as evaluated by investigators) * Patient under the protection of justice * Patient under guardianship or trusteeship Gastro-intestinal * Pre-existing chronic abdominal pain * History of inflammatory bowel disease * History of gastroparesis * History of gastric surgery, gastric embolization or radiotherapy * History of peptic ulcer * Significant risk factors for peptic ulcer, including daily use of non-steroidal anti-inflammatory drugs, active smoking or active infection with Helicobacter pylori * Abnormal upper digestive endoscopy Hepatic * Cirrhosis * Portal venous hypertension * Bilirubin \> 2,0 mg/dL * Albumin \< 2,5 g/L Cardiovascular * Known aortic pathology i.e. aneurysm or dissection * Severe peripheral arterial disease Renal \- Renal failure, Creatinine Clearance \< 60ml/min/1,73 m2 Hematologic/Immunologic/Oncologic/Infectious * Acute or chronic infection * Active cancer * Auto-immune disease requiring immunosuppression * Neutrophil count \< 1,5 x 10 \^ 9/L * Platelet count \< 100 x 10 \^ 9/L Contraindication to contrast medium Visipaque solution for injection * Hypersensitivity to the active substance (Iodixanol) or to any of the excipients * History of immediate major or delayed skin reaction to the injection of the product * Decompensated heart failure * Thyrotoxicosis * Contraindication to the use of the embogold microsphere