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Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths
Sponsor: University Hospital, Brest
Summary
The DEFI-1 study recruited 625 women witnesses and 299 of their spouses. With regard to case couples, 271 cases were recruited from the spontaneous repeated miscarriages (SRM) subgroup (≥3 spontaneous miscarriage (SM) from trimester 1 of pregnancy) and 93 from the unexplained fetal death in utero (FDIU) subgroup from trimesters 2 and 3 of pregnancy. The main objective of the DEFI 2 study is to increase the number of case-pairs in these 2 particular subgroups to replicate the results of the genetic determinants highlighted from cases and controls with extreme phenotypes and obtain a sufficient number of women with FDIUs to identify specific determinants.
Official title: Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths (DEFI-2)
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2020-10-05
Completion Date
2057-10-05
Last Updated
2026-03-20
Healthy Volunteers
No
Interventions
biological sample
biological samples will be taken from the subjects included
Locations (1)
BREST
Brest, France