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Perioperative Treatment of Combined SOX With Apatinib and Camrelizumab for Oesophagogastric Cancer
Sponsor: Ruijin Hospital
Summary
The study is being conducted to evaluate the efficacy, safety and tolerability of chemotherapy and apatinib with or without camrelizumab in the neoadjuvant (prior to surgery) or adjuvant (after surgery) treatment of previously untreated adults with gastric and gastroesophageal junction (GEJ) adenocarcinoma.
Official title: Perioperative Treatment of Combined SOX With Apatinib and Camrelizumab for Resectable Locally Advanced Gastric or Esophagogastric Junction Adenocarcinoma: A Multicenter, Randomized Phase II-III Trial
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
580
Start Date
2019-12-18
Completion Date
2027-12
Last Updated
2026-01-23
Healthy Volunteers
No
Interventions
Apatinib 250mg
Apatinib 250mg
Camrelizumab
Camrelizumab 200mg
S-1, Oxaliplatin
S-1, Oxaliplatin, q3w
Apatinib 500mg
Apatinib 500mg
Locations (23)
Affiliated Hospital of Hebei University
Baoding, China
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, China
Xiangya Hospital Central South University
Changsha, China
Heping Hospital Affiliated to Changzhi Medical College
Changzhi, China
Sichuan Cancer Hospital & Institute
Chengdu, China
Sichuan Provincial People's Hospital
Chengdu, China
The Affiliated Hospital of Guizhou Medical University
Guiyang, China
Hainan Cancer Hospital
Haikou, China
Cancer Hospital of the University of Chinese Academy of Sciences
Hangzhou, China
The Second Affiliated Hospital Zhejiang University School of Medicine
Hangzhou, China
Hefei Cancer Hospital, Chinese Academy of Sciences
Hefei, China
Lanzhou University Second Hospital
Lanzhou, China
Changhai Hospital
Shanghai, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, China
Liaoning Cancer Hospita & Institute
Shenyang, China
The Fourth Hospital of Hebei Medical University
Shijiazhuang, China
Jilin Guowen Hospital
Siping, China
Shanxi Provincial Cancer Hospital
Taiyuan, China
First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
Tangdu Hospital
Xi'an, China
Yantai Yuhuangding Hospital
Yantai, China
Henan Provincial Cancer Hospital
Zhengzhou, China
Affiliated Hospital of Jiangsu University
Zhenjiang, China