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Intraoperative Blood Pressure Management and Dexamethasone in Lung Cancer Surgery
Sponsor: Peking University First Hospital
Summary
Surgery is the front-line therapy for non-small cell lung cancer (NSCLC) but postoperative complications remains high and patients' long-term outcome is still challenging. In addition to surgery, anesthetic management particularly intraoperative blood pressure management and use of dexamethasone may affect patients' early and long-term outcomes after surgery for NSCLC. This study aims to investigate the impact of intraoperative blood pressure management and dexamethasone administration on early and long-term outcomes in patients undergoing surgery for lung cancer.
Official title: Impact of Intraoperative Blood Pressure Management and Dexamethasone on Patient's Outcomes After Lung Cancer Surgery: A 2 × 2 Factorial Randomized Controlled Trial
Key Details
Gender
All
Age Range
50 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
1988
Start Date
2020-04-07
Completion Date
2029-12
Last Updated
2025-07-31
Healthy Volunteers
No
Conditions
Interventions
Dexamethasone
Dexamethasone (10 mg/2 ml) is administered before anesthesia induction.
Targeted blood pressure management
Blood pressure is maintained within ±10% from baseline.
Placebo
Placebo (2 ml normal saline) is administered before anesthesia induction.
Routine blood presure management
Blood pressure is maintained according to routine practice.
Locations (1)
Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital
Beijing, Beijing Municipality, China