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Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block
Sponsor: Duke University
Summary
This prospective observational study aims to evaluate the incidence of hemidiaphragmatic paralysis in patients receiving interscalene brachial plexus nerve block with prolonged neural blockade. English speaking American Society of Anesthesiologists (ASA) 1-3 patients ages 18-80 receiving prolonged interscalene nerve block will be randomized into 3 groups: first group receiving a perineural catheter infusing 0.2% ropivacaine; the second group receiving a single shot injection of 10mL liposomal bupivacaine (Exparel; n=20) plus 5 mL 0.5% bupivacaine and the third receiving 20mL liposomal bupivacaine plus 5mL bupivacaine (to be determined by the attending anesthesiologist).Primary outcome will be incidence of hemidiaphragmatic paralysis postoperative day 1 as measured by point of care (POCUS) ultrasound.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2021-10-12
Completion Date
2026-08-31
Last Updated
2025-10-01
Healthy Volunteers
No
Conditions
Interventions
Ultrasound
Ultrasound guided evaluation of diaphragm ipsilateral to the block side.
Ropivacaine
Local anesthetic (numbing drug)
Bupivacaine
Local anesthetic (numbing drug)
MediPines AGM100 Advanced Respiratory Monitoring System
Non-invasive respiratory monitor to measure oxygenation and ventilation parameters
Locations (1)
Duke University Hospital
Durham, North Carolina, United States