Clinical Research Directory

Inclusion Criteria: 1. Diagnosed of recurrent nasopharyngeal carcinoma by pathology or imaging study; 2. Stage T1 or T2 according to AJCC 8th edition ; 3. Aged 18 to 70 years; 4. Without metastasis; 5. previously received 1 course of radiotherapy; 6. Without radiotherapy within 1 year, without local treatment for recurrent disease; 7. Surgical resectable and IMRT suitable; 8. If regional recurrence presented, regional lesion can be treated with local treatments. 9. ECOG score 0 or 1; 10. Sufficient organ function; 11. Acceptable approach of contraception. Exclusion Criteria: 1. Refuse to sign inform consent; 2. Radiation encephalopathy or leptomeningeal disease (LMD); 3. History of radioactive particle planting; 4. Have uncontrolled intercurrent illnesses which will interfere with the ability to undergo therapy; 5. With prior malignancy (excluding adequately treated basal cell or squamous cell skin cancer, in-situ cervical cancer ); 6. Any contradiction to surgery; 7. Have any co-existing condition that would preclude full compliance or safety with the study; 8. Presence of a significant neurological or psychiatric disease, including dementia and seizures; 9. Uncontrolled infectious diseases; 10. Female patients who are at pregnancy or lactation. 11. Without personal freedom or independent civil capacity. 12. With serious autoimmune disease. 13. Participants of other interventional clinical trial.