Clinical Research Directory

Inclusion Criteria: 1. Age ≥ 18 years old 2. Histologically-confirmed diagnosis of adenocarcinoma of the rectum 3. Distal part of the tumour within 2 to 12 cm of the anal margin 4. Candidate for Neoadjuvant chemotherapy (NAT) 5. Measurable disease (using the Recist criteria v1.1) 6. Eastern Cooperative Oncology Group (ECOG) performance status 0-1 7. General condition considered suitable for radical pelvic surgery 8. Adequate bone marrow, hepatic and renal function 9. Willing to participate to the study, and able to give informed consent and to comply with the treatment and follow-up schedules 10. Patient being able to follow all the treatment as well as the follow-ups planned in this study Exclusion Criteria: 1. Patient with metastatic disease 2. Symptomatic cardiac or coronary insufficiency 3. Severe renal insufficiency 4. Progressive active infection or any other severe medical condition 5. Other cancer treated within the last 5 years except in situ cervical carcinoma or basocellular/ spinocellular carcinoma 6. Pregnant or breast-feeding woman 7. Unaffiliated patient to French Social Protection System 8. Persons deprived of liberty or under guardianship or incapable of giving consent 9. Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol or follow-up schedule