Clinical Research Directory

Inclusion Criteria: 1. 60+ years old 2. Has UUI or urge-predominant mixed incontinence at least 5 times/ week for \> 3 months despite treatment for reversible causes Exclusion Criteria: 1. conditions/medications contraindicating trospium 2. If currently taking anticholinergic medications (participant must refrain from anticholinergic medications for 4 weeks prior enrollment in order to be eligible) 3. Impaired mobility or cognition sufficient to preclude following study procedures; MoCA test score \<24/30; a clinically-apparent neurological condition 4. Prolapse beyond the hymen 5. Interstitial cystitis 6. Spinal cord injury 7. History of pelvic radiation or advanced uterine/bladder cancer 8. Urethral obstruction (uroflow); PVR \>200 ml 9. Medical instability 10. Prior UUI treatment with onabotulinum toxin or neuromodulation 11. Drug interaction or expected medication change during the study 12. Conditions requiring IV antibacterial prophylaxis 13. New incontinence treatment \< 3 months prior to enrollment 14. Fecal incontinence, and symptomatic colitis/IBS 15. Contraindications to MRI.