Clinical Research Directory

Inclusion Criteria: * Meet DSM-5 criteria for OUD; * Age 21-60 yr; * Right handed; * Males and non-pregnant/non-lactating females; * cognitively intact (total IQ score \>80 on Shipley Institute of Living Scale); * Screening cardiovascular indices within ranges for safe use of the pharmacological stressor: resting HR 50-90 bpm, systolic BP 90-140 mmHg, and diastolic BP 50-90 mmHg; * Use alcohol and/or marijuana \<3 times/week; each "time" should consist of \<1 marijuana "joint" equivalent and \<3 alcoholic drinks. Exclusion Criteria: * Under influence of any substance during session; * Past 7-day use of illicit drugs other than opioids (except marijuana, which is legal in Michigan); * Urinalysis positive for cocaine metabolites, benzodiazepines, barbiturates, amphetamines or pregnancy; * Medical conditions prohibiting use of rTMS (e.g. seizure history; based on rTMS screening questionnaire); * Lifetime diagnosis of: psychotic disorder, bipolar disorder, generalized anxiety disorder, or obsessive compulsive disorder; major depression in the past 5 years; or potentially antisocial personality disorder (if the clinical psychologist judges such behaviors to be potentially disruptive or unsafe in our lab); * Past-year SUD other than OUD; * Acute/unstable illness: conditions making it unsafe for participation (e.g. neurological, cardiovascular, pulmonary, or systemic diseases); * Lactose intolerance (placebo dose); * Any prohibited medications: medications that lower seizure threshold, psychiatric medications, prescription pain medications, or blood pressure medications; * Chronic head or neck pain; and * Past-month participation in a research study.