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Application of Functional Renal MRI to Improve Assessment of Chronic Kidney Disease
Sponsor: University Hospitals of Derby and Burton NHS Foundation Trust
Summary
Research question: Can multiparametric renal Magnetic Resonance Imaging (MRI) provide structural and functional assessment of the kidneys to deliver prognostic information and guide treatment options in chronic kidney disease (CKD)? Aims and objectives: 1. To establish a multiparametric renal MRI protocol in CKD cohorts. 2. To use multiparametric MRI to characterise people with and without CKD progression. 3. To compare multiparametric renal MRI with 'gold-standard' renal biopsy to determine pathological processes of CKD progression that are detectable by MRI.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
450
Start Date
2021-06-01
Completion Date
2033-02-28
Last Updated
2023-03-31
Healthy Volunteers
No
Conditions
Interventions
Multiparametric renal MRI
Localiser scans; Kidney volume; Longitudinal (T1) relaxation time mapping; Diffusion weighted imaging (DWI); Phase Contrast MRI; Arterial spin labelling (ASL); Blood Oxygen Level Dependent (BOLD) mapping
Locations (1)
Royal Derby Hospital
Derby, Derbyshire, United Kingdom