Clinical Research Directory

Inclusion Criteria: * Adult patients, age ≥18 * Metastatic malignancy with at least 1 brain metastasis previously treated with SRS * Patients may have also received whole brain radiation therapy (WBRT) for management of brain metastatic disease but this is not required for study participation * Patients must have been diagnosed with a metastatic solid tumor of any histological type except small cell lung cancer (SCLC), or lymphoma. * Radiographic progression on post-SRS imaging at previously treated SRS site(s) * Must be a candidate for brain surgery as determined by treating neurosurgeon and/or anesthesia team * Patients must sign study-specific informed consent prior to study entry Exclusion Criteria: * Poor surgical candidate as determined by treating neurosurgeon and/or anesthesia team * Unable to undergo contrasted MRI (e.g. incompatible medical device, inadequate renal function per standard institutional clinical protocol, contrast allergy) * Small cell lung cancer (SCLC) or lymphoma histology