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Study of Bomedemstat in Participants With Essential Thrombocythemia (IMG-7289-CTP-201/MK-3543-003)
Sponsor: Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., (Rahway, New Jersey USA)
Summary
This is a Phase 2b open label study of an orally administered LSD1 inhibitor, Bomedemstat (MK-3543, formerly called IMG-7289), in patients with essential thrombocythemia. This study investigates the following: * The safety and tolerability of Bomedemstat * The pharmacodynamic effect of Bomedemstat
Official title: A Phase 2 Multi-Center, Open Label Study to Assess the Safety, Efficacy and Pharmacodynamics of IMG-7289 in Patients With Essential Thrombocythemia
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
73
Start Date
2020-09-08
Completion Date
2023-03-23
Last Updated
2026-05-04
Healthy Volunteers
No
Conditions
Interventions
Bomedemstat
Oral administration
Locations (26)
Local Institution
Jacksonville, Florida, United States
Local Institution
Ann Arbor, Michigan, United States
Local Institution
New York, New York, United States
Local Institution
Durham, North Carolina, United States
Cleveland Clinic
Cleveland, Ohio, United States
Local Institution
Pittsburgh, Pennsylvania, United States
Local Institution
Seattle, Washington, United States
Local Institution
Herston, Brisbane, Australia
Local Institution
Camperdown, New South Wales, Australia
Local Institution
St Leonards, New South Wales, Australia
Local Institution
Southport, Queensland, Australia
Royal Adelaide Hospital
Adelaide, South Australia, Australia
Local Institution
Clayton, Victoria, Australia
Department of Hematology and Stem Cell Transplantation, West German Cancer Center (WTZ)
Essen, Germany
Local Institution
Jena, Germany
Local Institution
Hong Kong, Hong Kong
Local Institution
Alessandria, Italy
Local Institution
Bologna, Italy
CRIMM; Centro Ricerca e Innovazione delle Malattia Mieloproliferative, Azienda ospedaliera Universitaria Careggi
Florence, Italy
Local Institution
Varese, Italy
Local Institution
Auckland, New Zealand
Middlemore Hospital
Auckland, New Zealand
Local Institution
London, United Kingdom
Guys and St Thomas Hospital
London, United Kingdom
Local Institution
London, United Kingdom
Local Institution
Oxford, United Kingdom