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NCT04255433

PHASE3

A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes

Sponsor: Eli Lilly and Company

View on ClinicalTrials.gov

Summary

The purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.

Official title: The Effect of Tirzepatide Versus Dulaglutide on Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes (SURPASS-CVOT)

Key Details

Gender

All

Age Range

40 Years - Any

Study Type

INTERVENTIONAL

Enrollment

13299

Start Date

2020-05-29

Completion Date

2025-06-12

Last Updated

2026-07-08

Healthy Volunteers

Conditions

Type 2 Diabetes Mellitus

Interventions

DRUG

Tirzepatide

Administered SC

DRUG

Dulaglutide

Administered SC

Inclusion Criteria: * Men or women at least 40 years old with a diagnosis of type 2 diabetes * Established cardiovascular disease, including at least 1 of the following: * Coronary artery disease (CAD) with any of the following: * Documented history of spontaneous myocardial infarction (MI) * ≥50% stenosis in 1 or more major coronary arteries, determined by invasive angiography * ≥50% stenosis in 2 or more major coronary arteries, determined by computed tomography coronary angiography (CTCA) * History of surgical or percutaneous coronary revascularization procedure * Cerebrovascular disease - any of the following: * Documented history of ischemic stroke * Carotid arterial disease with ≥50% stenosis, documented by carotid ultrasound, magnetic resonance imaging (MRI), or angiography * Carotid stenting or surgical revascularization * Peripheral arterial disease with either of the following: * Intermittent claudication and ankle-brachial index \<0.9 * Prior nontraumatic amputation or peripheral vascular procedure (eg, stenting or surgical revascularization), due to peripheral arterial ischemia * Note: Supporting medical documentation is required in all instances * HbA1c ≥7% (≥53 mmol/mol) and ≤10.5% (≤91.3 mmol/mol) based on central laboratory assessment at screening * Body mass index (BMI) ≥25 kg/m2 * At the time of signing the informed consent: Contraceptive use by men or women should be consistent with local regulations regarding the methods of contraception for those participating in clinical trials. * Male patients: Men, regardless of their fertility status, with nonpregnant women of childbearing potential (WOCBP) partners must agree to either remain abstinent (if this is their preferred and usual lifestyle) or use condoms, as well as 1 additional highly effective (less than 1% failure rate) method of contraception (such as combination oral contraceptives, implanted contraceptives, or intrauterine devices) or effective method of contraception (such as diaphragms with spermicide or cervical sponges) for the duration of the study and until their plasma concentrations are below the level that could result in a relevant potential exposure to a possible fetus, predicted to be 90 days following the last dose of study drug. * Men and their partners may choose to use a double-barrier method of contraception. (Barrier protection methods without concomitant use of a spermicide are not an effective or acceptable method of contraception. Thus, each barrier method must include use of a spermicide. It should be noted, however, that the use of male and female condoms as a double barrier method is not considered acceptable due to the high failure rate when these barrier methods are combined). * Periodic abstinence (eg, calendar, ovulation, symptothermal, or postovulation methods), declaration of abstinence just for the duration of a trial, and withdrawal are not acceptable methods of contraception. * Men with pregnant partners should use condoms during intercourse for the duration of the study and until the end of the estimated relevant potential exposure in WOCBP (90 days). Men should refrain from sperm donation for the duration of the study and until their plasma concentrations are below the level that could result in a relevant potential exposure to a possible fetus, predicted to be 90 days following the last dose of study drug. Men who are in exclusively same-sex relationships (as their preferred and usual lifestyle) are not required to use contraception. * Female patients: Women of childbearing potential who are abstinent (if this is complete abstinence, as their preferred and usual lifestyle) or in a same-sex relationship (as part of their preferred and usual lifestyle) must agree to either remain abstinent or stay in a same-sex relationship without sexual relationships with males. Periodic abstinence (eg, calendar, ovulation, symptothermal, or postovulation methods), declaration of abstinence just for the duration of a trial, and withdrawal are not acceptable methods of contraception. Otherwise, WOCBP participating must agree to use 2 forms of effective contraception, where at least 1 form is highly effective (less than 1% failure rate), for the entirety of the study. Contraception must continue following completion of study drug administration for the entirety of the study and for 30 days thereafter. * WOCBP participating must test negative for pregnancy prior to initiation of treatment as indicated by a negative serum pregnancy test at the screening visit followed by a negative urine pregnancy test within 24 hours prior to exposure. * Two forms of effective contraception, where at least 1 form is highly effective, (such as combination oral contraceptives, implanted contraceptives, or intrauterine devices) will be used. Effective contraception (such as male or female condoms with spermicide, diaphragms with spermicide, or cervical sponges) may be used as the second therapy. Barrier protection methods without concomitant use of a spermicide are not a reliable or acceptable method. Thus, each barrier method must include use of a spermicide (ie, condom with spermicide, diaphragm with spermicide, or female condom with spermicide). It should be noted that the use of male and female condoms as a double barrier method is not considered acceptable due to the high failure rate when these methods are combined. * Women not of childbearing potential may participate and include those who are: * infertile due to surgical sterilization (hysterectomy, bilateral oophorectomy, or tubal ligation), congenital anomaly such as mullerian agenesis, or * postmenopausal - defined as either: A woman at least 40 years of age with an intact uterus, not on hormone therapy, who has cessation of menses for at least 1 year without an alternative medical cause, AND a follicle-stimulating hormone \>40 mIU/mL; or ii. A woman 55 or older not on hormone therapy, who has had at least 12 months of spontaneous amenorrhea; or A woman at least 55 years of age with a diagnosis of menopause prior to starting hormone replacement therapy. * In the investigator's opinion, are well motivated, capable, and willing to: * learn how to self-inject treatment (tirzepatide or dulaglutide), as required for this protocol (visually impaired persons who are not able to perform the injections must have the assistance of a sighted individual trained to inject the study drug; persons with physical limitations who are not able to perform the injections must have the assistance of an individual trained to inject the study drug), * inject study drug weekly, * have a sufficient understanding of 1 of the provided languages of the country such that they will be able to complete the patient questionnaires, and * make themselves available for the duration of the study, and who will comply with the required study visits. * Capable of giving signed informed consent Exclusion Criteria: * Have type 1 diabetes mellitus * Have uncontrolled diabetes requiring immediate therapy (such as diabetic ketoacidosis) at screening or randomization, in the judgment of the physician * Have had 1 or more events of severe hypoglycemia and/or 1 or more events of hypoglycemia unawareness within 6 months prior to screening * Are currently planning treatment for diabetic retinopathy and/or macular edema. * Have been hospitalized for congestive heart failure (CHF) within 2 months prior to screening * Have chronic New York Heart Association Functional Classification IV CHF * Are currently planning a coronary, carotid, or peripheral artery revascularization * Had chronic or acute pancreatitis any time prior to screening, irrespective of etiology * Have a known clinically significant gastric emptying abnormality such as severe gastroparesis or gastric outlet obstruction, or have undergone or currently planning any gastric bypass (bariatric) surgery or restrictive bariatric surgery * Have acute or chronic hepatitis, signs or symptoms of any other liver disease, an alanine aminotransferase (ALT) level ≥3 times the upper limit of normal (ULN) for the reference range, as determined by the central laboratory (Note: Patients with nonalcoholic fatty liver disease are eligible to participate if their ALT level is \<3 times the ULN for the reference range) * Have known chronic severe renal failure (defined as a known estimated glomerular filtration rate (eGFR) \<15 mL/minute/1.73 m2) or are on chronic dialysis * Have evidence of a significant, uncontrolled endocrine abnormality (eg, thyrotoxicosis or adrenal crises) * Have a family or personal history of multiple endocrine neoplasia type 2 (MEN2) or familial medullary thyroid carcinoma (MTC) or personal history of nonfamilial MTC * Have a serum calcitonin level at screening of: (based on central laboratory results) * ≥20 ng/L at Visit 1, if eGFR ≥60 mL/min/1.73 m2, or * ≥35 ng/L at Visit 1, if eGFR \<60 mL/min/1.73 m2 * Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years. An exception for this criterion is basal or squamous cell skin cancer, in situ carcinomas of the cervix, or in situ prostate cancer * Have a history of any other condition (such as known drug or alcohol abuse or psychiatric disorder) that, in the opinion of the investigator, may preclude the patient from following and completing the protocol * Have had a transplanted organ (corneal transplants \[keratoplasty\] allowed) or awaiting an organ transplant * Have any other condition (eg, hypersensitivity) that is a contraindication to any incretin or glucagon-like peptide-1 (GLP-1) receptor agonist (RA) * Have had an MI, percutaneous coronary revascularization procedure, ischemic stroke, carotid stenting or surgical revascularization, nontraumatic amputation, or peripheral vascular procedure (eg, stenting or surgical revascularization) less than 60 days prior to screening * Have had coronary artery bypass graft surgery less than 5 years prior to screening * Have had a blood transfusion or severe blood loss within 90 days prior to screening or have known hematological conditions that may interfere with HbA1c measurement * Treatment with GLP-1 RA or pramlintide, in a period of 3 months prior to Visit 1 * Discontinuation of GLP-1 RA or pramlintide, due to intolerability any time prior to Visit 1 * Are currently enrolled in any other clinical study involving an investigational product or any other type of medical research judged not to be scientifically or medically compatible with this study * Have participated within the last 30 days in a clinical trial involving an investigational product. If the previous investigational product has a long half-life, 3 months or 5 half-lives (whichever is longer) should have passed * Have previously completed or withdrawn from this study or randomized into any other study investigating tirzepatide

Locations (635)

University of Alabama at Birmingham Medical Center

Birmingham, Alabama, United States

John Muir Medical Center - Concord Campus

Concord, California, United States

Valley Clinical Trials, Inc.

Covina, California, United States

AMCR Institute

Escondido, California, United States

Valley Research

Fresno, California, United States

NorCal Medical Research, Inc

Greenbrae, California, United States

UCSD - Altman Clinical and Translational Research Institute (ACTRI)

La Jolla, California, United States

First Valley Medical Group

Lancaster, California, United States

Monterey Endocrine & Diabetes Institute, Inc.

Monterey, California, United States

Riverside University Health System - Medical Center

Moreno Valley, California, United States

Diabetes Associates Medical Group

Orange, California, United States

Pasadena Clinical Research

Pasadena, California, United States

LCGK Research

San Carlos, California, United States

Norcal Endocrinology & Internal Medicine

San Ramon, California, United States

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Torrance, California, United States

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

CMR of Greater New Haven, LLC

Hamden, Connecticut, United States

Chase Medical Research, LLC

Waterbury, Connecticut, United States

Orlando Heart & Vascular Institute, LLC

Altamonte Springs, Florida, United States

Excel Medical Clinical Trials

Boca Raton, Florida, United States

Encore Medical Research

Hollywood, Florida, United States

East Coast Institute for Research, LLC

Jacksonville, Florida, United States

Jacksonville Center for Clinical Research

Jacksonville, Florida, United States

Accel Research Sites - St. Pete-Largo Clinical Research Unit

Largo, Florida, United States

Ocala Caridovascular Research

Ocala, Florida, United States

Cardiology Partners Clinical Research Institute - Palm Beach Gardens

Palm Beach Gardens, Florida, United States

Peace River Cardiovascular Center

Port Charlotte, Florida, United States

Professional Health Care of Pinellas

St. Petersburg, Florida, United States

Cardiology Partners Clinical Research Institute - Wellington

Wellington, Florida, United States

Clinical Research of Central Florida

Winter Haven, Florida, United States

Atlanta Diabetes Associates

Atlanta, Georgia, United States

Kaiser Permanente - Dutluth, GA

Duluth, Georgia, United States

NSC Research

Johns Creek, Georgia, United States

Physicians Research Associates

Lawrenceville, Georgia, United States

East Coast Institute for Research at The Jones Center

Macon, Georgia, United States

Atlanta Heart Specialists

Tucker, Georgia, United States

East-West Medical Research Institute

Honolulu, Hawaii, United States

VA Pacific Islands Health Care System

Honolulu, Hawaii, United States

Elite Clinical Trials

Blackfoot, Idaho, United States

Rocky Mountain Clinical Research

Idaho Falls, Idaho, United States

Northwest Heart Clinical Research

Arlington Heights, Illinois, United States

Cedar-Crosse Research Center

Chicago, Illinois, United States

Clinical Investigation Specialists

Gurnee, Illinois, United States

Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative

Springfield, Illinois, United States

University of Iowa

Iowa City, Iowa, United States

Iowa Diabetes and Endocrinology Research Center

West Des Moines, Iowa, United States

The University of Kansas - Clinical Research Center

Fairway, Kansas, United States

Cotton O'Neil Diabetes & Endocrinology

Topeka, Kansas, United States

Cotton O'Neil Mulvane

Topeka, Kansas, United States

Qualmedica Research

Bowling Green, Kentucky, United States

L-MARC Research Center

Louisville, Kentucky, United States

Qualmedica Research, LLC

Owensboro, Kentucky, United States

Ascension Saint Agnes Heart Care

Baltimore, Maryland, United States

MedStar Health Research Institute (MedStar Physician Based Research Network)

Hyattsville, Maryland, United States

MD Medical Research

Oxon Hill, Maryland, United States

Endocrine and Metabolic Consultants

Rockville, Maryland, United States

Brigham and Women's Hospital Diabetes Program

Boston, Massachusetts, United States

Joslin Diabetes Center

Boston, Massachusetts, United States

ActivMed Practices and Research

Methuen, Massachusetts, United States

Infinity Medical Research

North Dartmouth, Massachusetts, United States

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Troy, Michigan, United States

St. John's Hospital

Edina, Minnesota, United States

M Health Fairview St. John's Hospital

Maplewood, Minnesota, United States

CentraCare Heart & Vascular Center

Saint Cloud, Minnesota, United States

StudyMetrix Research

City of Saint Peters, Missouri, United States

Clinvest Research LLC

Springfield, Missouri, United States

Mercy Research - Smith Glynn Callaway

Springfield, Missouri, United States

Billings Clinic

Billings, Montana, United States

Mercury Street Medical Group, PLLC

Butte, Montana, United States

VA Nebraska-Western Iowa Health Care System

Omaha, Nebraska, United States

University Of Nebraska Medical Center

Omaha, Nebraska, United States

Palm Research Center Tenaya

Las Vegas, Nevada, United States

Palm Research Center Sunset

Las Vegas, Nevada, United States

Southern Nh Diabetes and Endocrinology

Nashua, New Hampshire, United States

Albany Medical College, Division of Community Endocrinology

Albany, New York, United States

Great Lakes Medical Research, LLC

Westfield, New York, United States

Atrium Health - Department of Family Medicine Research

Charlotte, North Carolina, United States

Duke University

Durham, North Carolina, United States

PMG Research Inc., d/b/a PMG of Piedmont Healthcare

Mooresville, North Carolina, United States

Accellacare - Wilmington

Wilmington, North Carolina, United States

Lillestol Research

Fargo, North Dakota, United States

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Alliance for Multispecialty Research, LLC

Norman, Oklahoma, United States

Heritage Valley Medical Group, Inc.

Beaver, Pennsylvania, United States

Capital Area Research, LLC

Camp Hill, Pennsylvania, United States

Decpa, Llc

Feasterville, Pennsylvania, United States

Thomas Jefferson University - Clinical Research Institute

Philadelphia, Pennsylvania, United States

Northeast Endocrine Metabolic Associates

Philadelphia, Pennsylvania, United States

Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)

Pittsburgh, Pennsylvania, United States

Cardiology Consultants of Philadelphia Yardley

Yardley, Pennsylvania, United States

Ralph H. Johnson VA Medical Center

Charleston, South Carolina, United States

Tribe Clinical Research, LLC

Greenville, South Carolina, United States

Accellacare - Mt Pleasant

Mt. Pleasant, South Carolina, United States

Monument Health Rapid City Hospital

Rapid City, South Dakota, United States

Holston Medical Group

Bristol, Tennessee, United States

PMG Research, Inc. d/b/a PMG Research of Knoxville

Knoxville, Tennessee, United States

Endocrine Clinic

Memphis, Tennessee, United States

Private Practice - Dr. Osvaldo A. Brusco

Corpus Christi, Texas, United States

Dallas Diabetes Research Center

Dallas, Texas, United States

North Texas Endocrine Center

Dallas, Texas, United States

Research Institute of Dallas

Dallas, Texas, United States

Texas Health Physicians Group

Dallas, Texas, United States

Galenos Research

Dallas, Texas, United States

Academy of Diabetes, Thyroid and Endocrine

El Paso, Texas, United States

Diabetes and Thyroid Center of Ft. Worth

Fort Worth, Texas, United States

Northwest Houston Cardiology - Cypress

Houston, Texas, United States

Southern Endocrinology Associates

Mesquite, Texas, United States

North Hills Family Medicine/North Hills Medical Research

North Richland Hills, Texas, United States

Audie L Murphy VA Hospital

San Antonio, Texas, United States

Consano Clinical Research, LLC

Shavano Park, Texas, United States

Northwest Houston Heart Center

Tomball, Texas, United States

Physicians' Research Options

Draper, Utah, United States

Advanced Research Institute

Ogden, Utah, United States

Alpine Medical Group

Salt Lake City, Utah, United States

Kalo Clinical Research

West Valley City, Utah, United States

Virginia Heart

Falls Church, Virginia, United States

MultiCare Good Samaritan Hospital

Puyallup, Washington, United States

VA Puget Sound Health Care System

Seattle, Washington, United States

Multicare Institute for Research and Innovation

Spokane, Washington, United States

Central Washington Health Services Association d/b/a Confluence Health

Wenatchee, Washington, United States

Clinical Investigation Specialists

Kenosha, Wisconsin, United States

Instituto de Investigaciones Clínicas Bahia Blanca

Bahía Blanca, Buenos Aires, Argentina

Organizacion Medica de Investigacion

CABA, Buenos Aires, Argentina

CEDIC

CABA, Buenos Aires, Argentina

Stat Research S.A.

Capital Federal, Buenos Aires, Argentina

Centro de Investigaciones Metabólicas (CINME)

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Instituto de Investigaciones Clínicas Mar del Plata

Mar del Plata, Buenos Aires, Argentina

DIM Clínica Privada

Ramos Mejía, Buenos Aires, Argentina

Go Centro Medico San Nicolás

San Nicolás de los Arroyos, Buenos Aires, Argentina

Instituto de Investigaciones Clinicas Zarate

Zárate, Buenos Aires, Argentina

Centro Médico Viamonte

Buenos Aires, Buenos Aires F.D., Argentina

Mautalen Salud e Investigación

Buenos Aires, Buenos Aires F.D., Argentina

Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

Buenos Aires, Buenos Aires F.D., Argentina

CEMEDIAB

C.a.b.a., Buenos Aires F.D., Argentina

Centro Medico Privado CEMAIC

Capital, Córdoba Province, Argentina

Centro Medico Privado San Vicente Diabetes

Córdoba, Córdoba Province, Argentina

Instituto Médico Catamarca IMEC

Rosario, Santa Fe Province, Argentina

Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica

Rosario, Santa Fe Province, Argentina

Instituto de Investigaciones Clinicas Rosario

Rosario, Santa Fe Province, Argentina

Centro de Investigaciones Médicas Tucuman

SAN M. de Tucuman, Tucumán Province, Argentina

Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L

San Miguel de Tucumán, Tucumán Province, Argentina

Investigaciones Clínicas Tucumán

San Miguel de Tucumán, Tucumán Province, Argentina

CEMEDIC

Buenos Aires, Argentina

Glenny Corp

Buenos Aires, Argentina

CIPREC

Buenos Aires, Argentina

Asociación de Beneficencia Hospital Sirio Libanés

Buenos Aires, Argentina

Centro Universitario de Investigación en Farmacologia Clínic

Corrientes, Argentina

Instituto de Cardiología "Juana F. Cabral"

Corrientes, Argentina

CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani

Córdoba, Argentina

Centro Diabetológico Dr. Waitman

Córdoba, Argentina

Instituto Médico Alas

Salta, Argentina

Sanatorio Norte

Santiago del Estero, Argentina

The AIM Centre / Hunter Diabetes Centre

Merewether, New South Wales, Australia

Nepean Hospital

Penrith, New South Wales, Australia

University of Sydney - Charles Perkins Centre

Sydney, New South Wales, Australia

Illawarra Shoalhaven Local Health District

Wollongong, New South Wales, Australia

Royal Brisbane and Women's Hospital

Brisbane, Queensland, Australia

Core Research Group

Brisbane, Queensland, Australia

Mater Misericordiae Limited

Brisbane, Queensland, Australia

Gold Coast University Hospital

Southport, Queensland, Australia

The Townsville Hospital

Townsville, Queensland, Australia

Nightingale Research

Adelaide, South Australia, Australia

Royal Adelaide Hospital

Adelaide, South Australia, Australia

Southern Adelaide Diabetes & Endocrine Services

Oaklands Park, South Australia, Australia

Launceston General Hospital

Launceston, Tasmania, Australia

Box Hill Hospital

Box Hill, Victoria, Australia

Victorian Heart Hospital

Clayton, Victoria, Australia

Barwon Health

Geelong, Victoria, Australia

Austin Health - Repatriation Hospital

Heidelberg West, Victoria, Australia

School of Medicine, Fremantle Hospital

Fremantle, Western Australia, Australia

Advara HeartCare Joondalup

Joondalup, Western Australia, Australia

GenesisCare - Murdoch - Murdoch Drive

Murdoch, Western Australia, Australia

Medizinische Universität Graz

Graz, Styria, Austria

Uniklinikum Salzburg

Salzburg, Austria

Klinik Landstraße

Vienna, Austria

Zentrum für klinische Studien Dr Hanusch Gmbh

Vienna, Austria

Universitaetsklinikum Allgemeines Krankenhaus Wien

Vienna, Austria

Klinik Hietzing

Vienna, Austria

Imelda General Hospital

Bonheiden, Antwerpen, Belgium

Algemeen Ziekenhuis klina

Brasschaat, Antwerpen, Belgium

Antwerp University Hospital

Edegem, Antwerpen, Belgium

Université Libre de Bruxelles - Hôpital Erasme

Brussels, Bruxelles-Capitale, Région de, Belgium

UZ Brussel

Brussels, Bruxelles-Capitale, Région de, Belgium

ZAS Jan Palfijn

Merksem, Flanders, Belgium

AZORG Campus Aalst-Moorselbaan

Aalst, Oost-Vlaanderen, Belgium

AZ Nikolaas

Sint-Niklaas, Oost-Vlaanderen, Belgium

UZ Leuven

Leuven, Vlaams-Brabant, Belgium

AZ Sint-Jan Brugge-Oostende AV

Bruges, West-Vlaanderen, Belgium

AZ Groeninge Campus Kennedylaan

Kortrijk, West-Vlaanderen, Belgium

Az Damiaan vzw

Ostend, West-Vlaanderen, Belgium

AZ Delta vzw

Roeselare, West-Vlaanderen, Belgium

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman

Liège, Belgium

Private Practice - Dr.Miguel N. Hissa

Fortaleza, Ceará, Brazil

CEDOES

Vitória, Espírito Santo, Brazil

Quanta Diagnóstico e Terapia

Curitiba, Paraná, Brazil

Núcleo de Pesquisa Clínica do Rio Grande do Sul

Porto Alegre, Rio Grande do Sul, Brazil

Instituto de Pesquisa clinica de Campinas

Campinas, São Paulo, Brazil

Loema Instituto de Pesquisa Clinica

Campinas, São Paulo, Brazil

CECIP - Centro de Estudos do Interior Paulista

Jaú, São Paulo, Brazil

Faculdade de Medicina do ABC

Santo André, São Paulo, Brazil

ISPEM - Instituto São José dos Campos em Pesquisas Médicas

São José dos Campos, São Paulo, Brazil

Instituto de Pesquisa Clinica

São Paulo, São Paulo, Brazil

CPCLIN

São Paulo, São Paulo, Brazil

IBPClin - Instituto Brasil de Pesquisa Clínica

Rio de Janeiro, Brazil

CPQuali Pesquisa Clínica

São Paulo, Brazil

Hospital das Clinicas FMUSP

São Paulo, Brazil

Hospital das Clinicas FMUSP

São Paulo, Brazil

LMC Diabetes & Endocrinology

Calgary, Alberta, Canada

BC Diabetes Office

Vancouver, British Columbia, Canada

Dr. M.B. Jones Inc.

Victoria, British Columbia, Canada

Winnipeg Clinic

Winnipeg, Manitoba, Canada

NSHA-QEII Health Sciences Centre-Dickson Bldg

Halifax, Nova Scotia, Canada

LMC Clinical Research Inc. (Barrie)

Barrie, Ontario, Canada

LMC Diabetes & Endocrinology

Brampton, Ontario, Canada

Aggarwal and Associates Limited

Brampton, Ontario, Canada

Cambridge Cardiac Care Centre

Cambridge, Ontario, Canada

LMC Clinical Research Inc. (Thornhill)

Concord, Ontario, Canada

Janik Research Corporation

Greater Sudbury, Ontario, Canada

Milestone Research Inc.

London, Ontario, Canada

St. Joseph's Health Care

London, Ontario, Canada

North York Diagnostic and Cardiac Centre

North York, Ontario, Canada

LMC Clinical Research Inc. (Oakville)

Oakville, Ontario, Canada

Private Practice - Dr. James Cha

Oshawa, Ontario, Canada

LMC Manna Research

Ottawa, Ontario, Canada

Kawartha Cardiology Clinical Trials

Peterborough, Ontario, Canada

Bluewater Clinical Research Group Inc.

Sarnia, Ontario, Canada

Diabetes Clinic

Smiths Falls, Ontario, Canada

Canadian Phase Onward

Toronto, Ontario, Canada

LMC Clinical Research Inc. (Bayview)

Toronto, Ontario, Canada

Diabetes Heart Research Centre

Toronto, Ontario, Canada

Dr. Anil K. Gupta Medicine Professional Corporation

Toronto, Ontario, Canada

Viacar Recherche Clinique

Greenfield Park, Quebec, Canada

Centre de Recherche Clinique de Laval

Laval, Quebec, Canada

Manna Research

Lévis, Quebec, Canada

Clinique Sante Cardio MC

Montreal, Quebec, Canada

Diex Recherche Quebec

Québec, Canada

Beijing Anzhen Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Peking University First Hospital

Beijing, Beijing Municipality, China

Peking University People's Hospital

Beijing, Beijing Municipality, China

Beijing Friendship Hospital

Beijing, Beijing Municipality, China

The First Hospital of Lanzhou University

Lanzhou, Gansu, China

Lanzhou university second hospital

Lanzhou, Gansu, China

The First Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, China

The Fourth Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China

Hunan Provincial People's Hospital

Changsha, Hunan, China

First Huai'an Hospital Affiliated to Nanjing Medical University

Huai'an, Jiangsu, China

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

Nanjing, Jiangsu, China

Zhongda Hospital Southeast University

Nanjing, Jiangsu, China

The Second Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, China

Nanjing First Hospital

Nanjing, Jiangsu, China

Affiliated Hospital of Jiangsu University

Zhenjiang, Jiangsu, China

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China

Jiangxi Pingxiang People's Hospital

Pingxiang, Jiangxi, China

China-Japan Union Hospital

Changchun, Jilin, China

The People's Hospital of Liaoning Province

Shenyang, Liaoning, China

General Hospital of Ningxia Medical University

Yinchuan, Ningxia, China

The First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, Shaanxi, China

Jinan Central Hospital

Jinan, Shandong, China

Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, China

MUDr. Tomas Edelsberger

Krnov, Moravian-Silesian Region, Czechia

Interni a diabetologicka ordinace, s.r.o.

Náchod, Náchod, Czechia

Diabet2 s.r.o., diabetologicka a interni ambulance

Prague, Praha 1, Czechia

ResTrial s.r.o.

Prague, Praha 8, Czechia

MUDr. Barbora Diepoltova

Praha 9 - Klanovice, Praha 9, Czechia

Diacentrum Brandys n.L. s.r.o.

Brandýs nad Labem, Praha-východ, Czechia

MUDr. Alena Vachova

České Budějovice, South Bohemian Region, Czechia

Vseobecna fakultni nemocnice v Praze

Prague, Czechia

MUDr. Michala Pelikanova s.r.o.

Prague, Czechia

Milan Kvapil s.r.o., Diabetologicka ambulance

Prague, Czechia

CHU Bordeaux Haut-Leveque

Pessac, Aquitaine, France

Groupe Hospitalier Mutualiste Les Portes du Sud

Vénissieux, Auvergne-Rhône-Alpes, France

Hôtel-Dieu du Creusot - site Harfleur

Le Creusot, Bourgogne-Franche-Comté, France

Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand

Dijon, Côte-d'Or, France

CHU Rangueil

Toulouse, Haute-Garonne, France

Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes

Saint-Herblain, Loire-Atlantique, France

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois

Vandœuvre-lès-Nancy, Lorraine, France

Assistance Publique Hôpitaux de Paris - Groupe Hospitalier 10e - Hôpital Lariboisière

Paris, France

Hôpital Bichat - Claude-Bernard

Paris, France

Centre Hospitalier Sud Francilien

Corbeil-Essonnes, Île-de-France Region, France

Groupe hospitalier Paris saint Joseph

Paris, Île-de-France Region, France

Gemeinschaftspraxis Dres. Jung

Deggingen, Baden-Wurttemberg, Germany

Marienhospital Stuttgart

Stuttgart, Baden-Wurttemberg, Germany

Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob, Dr. med. Frohmut Jacob

Villingen-Schwenningen, Baden-Wurttemberg, Germany

Praxis Sauter & Sauter & Vorbach

Wangen, Baden-Wurttemberg, Germany

CIMS Studienzentrum Bamberg

Bamberg, Bavaria, Germany

Private Practice - Dr. Ilka Simon-Wagner

Lichtenfels, Bavaria, Germany

CDG Studienambulanz Hartard

München, Bavaria, Germany

ZKS Suedbrandenburg

Elsterwerda, Brandenburg, Germany

ZKS Dr. Lüdemann

Falkensee, Brandenburg, Germany

ClinPhenomics GmbH & Co KG

Frankfurt am Main, Hesse, Germany

MVZ im Altstadt-Carree Fulda GmbH

Fulda, Hesse, Germany

Diabetes Zentrum Dr. Tews

Gelnhausen, Hesse, Germany

Diabetologische Schwerpunktpraxis Marck Linn Pickel

Pohlheim, Hesse, Germany

Praxis Oedeme

Lüneburg, Lower Saxony, Germany

Praxis Dr. Veronika Wenzl-Bauer

Rehlingen, Lower Saxony, Germany

Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen

Bad Oeynhausen, North Rhine-Westphalia, Germany

Diabetes- und Stoffwechselpraxis Bochum

Bochum, North Rhine-Westphalia, Germany

Private Practice - Dr. Claus Busch, Dr. Christian Busch & Dr. Christopher Cramer

Dortmund, North Rhine-Westphalia, Germany

InnoDiab Forschung Gmbh

Essen, North Rhine-Westphalia, Germany

Medizentrum Essen Borbeck

Essen, North Rhine-Westphalia, Germany

Private Practice - Dr. Bernd Becker

Essen, North Rhine-Westphalia, Germany

Institut für Diabetesforschung GmbH Münster

Münster, North Rhine-Westphalia, Germany

Diabetologikum Ludwigshafen/Die Praxis am Ludwigsplatz

Ludwigshafen am Rhein, Rhineland-Palatinate, Germany

Diabetologische Schwerpunktpraxis Diabetologikum Speyer

Speyer, Rhineland-Palatinate, Germany

Practice Dr.med. Denger and Dr.med. Pfitzner

Friedrichsthal, Saarland, Germany

Zentrum für klinische Studien

Saint Ingbert, Saarland, Germany

Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien

Dresden, Saxony, Germany

Universitaetsklinikum Carl Gustav Carus Dresden

Dresden, Saxony, Germany

Velocity Clinical Research Leipzig GmbH

Leipzig, Saxony, Germany

Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut

Leipzig, Saxony, Germany

AmBeNet GmbH

Leipzig, Saxony, Germany

Private Practice - Dr. Christine Kosch

Pirna, Saxony, Germany

MVZ Riesa am Klinikum Döbeln GmbH

Riesa, Saxony, Germany

Praxis für Inner Medizin - Diabetologische Schwerpunktpraxis

Zwenkau, Saxony, Germany

Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels

Hohenmölsen, Saxony-Anhalt, Germany

SMO.MD GmbH

Magdeburg, Saxony-Anhalt, Germany

Universität zu Lübeck - Institut für Endokrinologie und Diabetes

Lübeck, Schleswig-Holstein, Germany

RED-Institut GmbH

Oldenburg in Holstein, Schleswig-Holstein, Germany

Private Practice - Dr. Joachim Weimer

Reinfeld, Schleswig-Holstein, Germany

Medizinisches Versorgungszentrum am Bahnhof Spandau

Spandau, State of Berlin, Germany

Gemeinschaftspraxis für Diabetologie

Eisenach, Thuringia, Germany

Institut für klinische Forschung und Entwicklung

Berlin, Germany

Diabetespraxis Prenzlauer Alle

Berlin, Germany

Diabetologische Schwerpunktpraxis Harburg

Hamburg, Germany

Diabetes Zentrum Wilhelmsburg

Hamburg, Germany

Diabeteszentrum Hamburg West

Hamburg, Germany

St. Josefskrankenhaus Heidelberg

Heidelberg, Germany

Athens Euroclinic

Athens, Attikí (Region), Greece

Iatriko Paleou Falirou Medical Center

Palaió Fáliro, Attikí (Region), Greece

General Hospital of Athens "G. Gennimatas"

Athens, Attikí, Greece

Attikon General University Hospital

Chaïdári, Attikí, Greece

Ippokrateio General Hospital of Thessaloniki

Thessaloniki, Kentrikí Makedonía, Greece

Thermi Clinic

Thermi, Thessaloniki, Thessaloníki, Greece

AHEPA University General Hospital of Thessaloniki

Thessaloniki, Thessaloníki, Greece

Euromedica General Clinic of Thessaloniki

Thessaloniki, Thessaloníki, Greece

Papageorgiou General Hospital of Thessaloniki

Thessaloniki, Thessaloníki, Greece

University General Hospital of Larissa

Larissa, Thessalía, Greece

Studium Egeszseghaz Kft

Kalocsa, Bács-Kiskun county, Hungary

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ

Szeged, Csongrád megye, Hungary

Fejér Megyei Szent György Egyetemi Oktató Kórház

Székesfehérvár, Fejér, Hungary

Debreceni Egyetem Kenézy Gyula Egyetemi Kórház

Debrecen, Hajdú-Bihar, Hungary

Markhot Ferenc Oktatókórház

Eger, Heves County, Hungary

Pharma 4 Trial

Gyöngyös, Heves County, Hungary

Selye János Kórház

Komárom, Komárom-Esztergom, Hungary

CLINFAN Szolgáltató Kft

Szekszárd, Tolna County, Hungary

DRC Gyógyszervizsgáló Központ

Balatonfüred, Veszprém megye, Hungary

Kanizsai Dorottya Korhaz

Nagykanizsa, Zala County, Hungary

Zala Megyei Szent Rafael Kórház

Zalaegerszeg, Zala County, Hungary

Szent Margit Rendelőintézet Nonprofit Kft

Budapest, Hungary

ClinDiab Kft.

Budapest, Hungary

Szent János Kórház

Budapest, Hungary

Magyar Honvedseg Egeszsegugyi Kozpont

Budapest, Hungary

Strazsahegy Medicina Bt.

Budapest, Hungary

Debreceni Egyetem Klinikai Kozpont

Debrecen, Hungary

Gujarat Endocrin Pvt Ltd

Ahmedabad, Gujarat, India

Marengo CIMS Hospital

Ahmedabad, Gujarat, India

Bangalore Diabetes Centre

Bangalore, Karnataka, India

CARE CHL-Hospitals

Indore, Madhya Pradesh, India

Topiwala National Medical College & B. Y. L. Nair Charitable Hospital

Mumbai, Maharashtra, India

King Edward Memorial Hospital & Seth Gordhandas Sunderdas Medical College

Mumbai, Maharashtra, India

Kingsway Hospitals (Best Multispeciality Hospital in Nagpur)

Nagpur, Maharashtra, India

G.B. Pant Institute of Postgraduate Medical Education & Research

New Delhi, National Capital Territory of Delhi, India

All India Institute of Medical Sciences

New Delhi, National Capital Territory of Delhi, India

Sir Ganga Ram Hospital

New Delhi, National Capital Territory of Delhi, India

Batra Hospital and Medical Research Centre

New Delhi, National Capital Territory of Delhi, India

Madras Diabetes Research Foundation

Chennai, Tamil Nadu, India

Care Hospitals Hyderabad- Banjara Hills

Hyderabad, Telangana, India

Apollo Multispeciality Hospitals limited

Kolkata, West Bengal, India

Edith Wolfson Medical Center

Holon, Central District, Israel

Meir Medical Center

Kfar Saba, Central District, Israel

Rabin Medical Center - Hasharon Campus

Petah Tikva, Central District, Israel

Rabin Medical Center

Petah Tikva, Central District, Israel

Sheba Medical Center

Ramat Gan, Central District, Israel

Kaplan Medical Center

Rehovot, Central District, Israel

Shaare Zedek Medical Center

Jerusalem, Jerusalem, Israel

Hadassah Medical Center

Jerusalem, Jerusalem, Israel

Hadassah Mount Scopus Medical Centre

Jerusalem, Jerusalem, Israel

Clalit Health Services Diabetes and Endocrinology Clinic Jerusalem

Jerusalem, Jerusalem, Israel

Emek Medical Center

Afula, Northern District, Israel

Hillel Yaffe Medical Center

Hadera, Northern District, Israel

Rambam Health Care Campus

Haifa, Northern District, Israel

Galilee Medical Center

Nahariya, Northern District, Israel

Holy Family Hospital

Nazareth, Northern District, Israel

ZIV Medical Center

Safed, Northern District, Israel

Clalit Health Services - Sakhnin Community Clinic

Sakhnin, Northern District, Israel

Barzilai Medical Center

Ashkelon, Southern District, Israel

Soroka Medical Center

Beersheba, Southern District, Israel

Sourasky Medical Center

Tel Aviv, Tell Abīb, Israel

Clalit Health Services - Atlit

Atlit, Ḥeifā, Israel

Bnai Zion Medical Center

Haifa, Ḥeifā, Israel

Linn Medical Center

Haifa, Ḥeifā, Israel

A.O.U.C. Policlinico di Bari

Bari, Apulia, Italy

Universita degli Studi della Campania Luigi Vanvitelli

Naples, Campania, Italy

Fondazione Policlinico Tor Vergata

Rome, Lazio, Italy

Fondazione Policlinico Universitario Agostino Gemelli

Rome, Lazio, Italy

Ospedale San Giovanni Calibita Fatebenefratelli

Rome, Lazio, Italy

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII

Bergamo, Lombardy, Italy

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

Milan, Lombardy, Italy

Ospedale san Giovanni di Dio-Diabetologia

Olbia, Sardinia, Italy

A.O.U. Policlinico Paolo Giaccone

Palermo, Sicily, Italy

Ospedale Maggiore Pronto Soccorso

Chieri, Torino, Italy

Azienda Ospedaliera Universitaria Careggi

Florence, Tuscany, Italy

Azienda Ospedaliera Universitaria Pisana

Pisa, Tuscany, Italy

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento

Verona, Veneto, Italy

IRCCS - AOU di Bologna

Bologna, Italy

Azienda Ospedaliera Garibaldi

Catania, Italy

Azienda Ospedaliera Mater Domini

Catanzaro, Italy

Università degli Studi Gabriele D' Annunzio

Chieti, Italy

Centro Cardiologico Monzino

Milan, Italy

Azienda Ospedaliero Universitaria di Parma

Parma, Italy

Fondazione Salvatore Maugeri Clinica del lavoro

Pavia, Italy

Uji-Tokushukai Medical Center

Uji, Kyoto, Japan

Takatsuki Red Cross Hospital

Takatsuki, Osaka, Japan

The Institute of Medical Science, Asahi Life Foundation

Chuo-ku, Tokyo, Japan

Tokyo-Eki Center-building Clinic

Chuo-ku, Tokyo, Japan

Fukuwa Clinic

Chuo-ku, Tokyo, Japan

Medical Corporation Sato Medical clinic

Ootaku, Tokyo, Japan

Jinnouchi Hospital

Kumamoto, Japan

AMC Nishiumeda Clinic

Osaka, Japan

Sakurabashi Watanabe Advanced Healthcare Hospital

Osaka, Japan

Centro de Investigacion Cardiovascular y Metabólica

Tijuana, Estado de Baja California, Mexico

Diseno y Planeacion en Investigacion Medica

Guadalajara, Jalisco, Mexico

Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente

Guadalajara, Jalisco, Mexico

Centro de Investigacion Medica Integral

Guadalajara, Jalisco, Mexico

Centro de Investigacion Medica de Occidente, S.C.

Guadalajara, Jalisco, Mexico

Universidad de Guadalajara

Guadalajara, Jalisco, Mexico

Instituto Jalisciense de Investigacion en Diabetes y Obesidad

Guadalajara, Jalisco, Mexico

Private Practice - Dr. Arechavaleta Granell Maria del Rosario

Guadalajara, Jalisco, Mexico

Salud Cardiovascular

Guadalajara, Jalisco, Mexico

Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares

Mexico City, Mexico City, Mexico

Instituto de Diabetes, Obesidad y Nutricion

Cuernavaca, Morelos, Mexico

Cardiolink Clin Trials

Monterrey, Nuevo León, Mexico

Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

Monterrey, Nuevo León, Mexico

Unidad Médica para la Salud Integral

San Nicolás de los Garza, Nuevo León, Mexico

Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.

Culiacán, Sinaloa, Mexico

Centro de Estudios de Investigacion Metabolicos y Cardiovasculares

Ciudad Madero, Tamaulipas, Mexico

Hospital Angeles Xalapa

Xalapa, Veracruz, Mexico

Medical Care and Research SA de CV

Mérida, Yucatán, Mexico

Centro de Investigacion Medica Aguascalientes

Aguascalientes, Mexico

Fundación Cardiovascular de Aguascalientes A.C.

Aguascalientes, Mexico

Hospital Cardiologica Aguescalientes

Aguascalientes, Mexico

Investigacion En Salud Y Metabolismo S.C / Nutricion Clinica / Unidad de Base de Datos

Chihuahua City, Mexico

Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia

Durango, Mexico

Centro de Estudios Clínicos de Querétaro (CECLIQ)

Querétaro, Mexico

Ziekenhuis Bethesda

Hoogeveen, Drenthe, Netherlands

EB Utrecht

Almere Stad, Flevoland, Netherlands

Ziekenhuis Rijnstate

Arnhem, Gelderland, Netherlands

Slingeland Ziekenhuis

Doetinchem, Gelderland, Netherlands

Ziekenhuis Gelderse Vallei

Ede, Gelderland, Netherlands

Radboudumc

Nijmegen, Gelderland, Netherlands

Canisius-Wilhelmina Ziekenhuis

Nijmegen, Gelderland, Netherlands

Jeroen Bosch ziekenhuis

's-Hertogenbosch, North Brabant, Netherlands

Ziekenhuis Amstelland

Amstelveen, North Holland, Netherlands

Amsterdam UMC, locatie VUmc

Amsterdam, North Holland, Netherlands

Amsterdam UMC, locatie AMC

Amsterdam, North Holland, Netherlands

Spaarne Gasthuis, Haarlem Zuid

Haarlem, North Holland, Netherlands

Saxenburgh Medisch Centrum

Hardenberg, Overijssel, Netherlands

Reinier de Graaf Ziekenhuis, locatie Delft

Delft, South Holland, Netherlands

Het Van Weel-Bethesda Ziekenhuis - Ziekenhuis Dirksland

Dirksland, South Holland, Netherlands

Franciscus Gasthuis & Vlietland, Locatie Gasthuis

Rotterdam, South Holland, Netherlands

Diakonessenhuis, locatie Utrecht

Utrecht, Netherlands

Universitair Medisch Centrum Utrecht

Utrecht, Netherlands

OMEDICA Medical Center

Poznan, Greater Poland Voivodeship, Poland

Gaja Poradnie Lekarskie Maciej Wiza

Poznan, Greater Poland Voivodeship, Poland

Private Practice - Dr. Ewa Krzyzagorska

Poznan, Greater Poland Voivodeship, Poland

Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET

Krakow, Lesser Poland Voivodeship, Poland

Private Practice - Dr. Robert Witek

Tarnów, Lesser Poland Voivodeship, Poland

NZOZ Regionalna Poradnia Diabetologiczna

Wroclaw, Lower Silesian Voivodeship, Poland

Wojewódzki Zespól Specjalistycznej Opieki Zdrowotnej

Wroclaw, Lower Silesian Voivodeship, Poland

CenterMed Lublin NZOZ

Lublin, Lublin Voivodeship, Poland

Gabinety TERPA

Lublin, Lublin Voivodeship, Poland

NZOZ Medica

Lublin, Lublin Voivodeship, Poland

Centrum Medyczne AMED

Warsaw, Masovian Voivodeship, Poland

Instytut Diabetologii

Warsaw, Masovian Voivodeship, Poland

ETG NETWORK Sp. z o.o.

Warsaw, Masovian Voivodeship, Poland

Legeartis - Poradnie Specjalistyczne

Bialystok, Podlaskie Voivodeship, Poland

Niepubliczny Specjalistyczny Zaklad Opieki Zdrowotnej Osrodek Diabetologiczny Popula Spolka Cywilna

Bialystok, Podlaskie Voivodeship, Poland

Centrum Badan Klinicznych PI-House sp. z o.o.

Gdansk, Pomeranian Voivodeship, Poland

NZOZ Salvia CM

Katowice, Silesian Voivodeship, Poland

NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki

Ruda Śląska, Silesian Voivodeship, Poland

Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

Lodz, Łódź Voivodeship, Poland

Advanced Clinical Research, LLC

Bayamón, Puerto Rico

Manati Center for Clinical Research

Manati, Puerto Rico

Research and Cardiovascular Corp.

Ponce, Puerto Rico

GCM Medical Group, PSC - Hato Rey Site

San Juan, Puerto Rico

San Juan City Hospital

San Juan, Puerto Rico

Private Practice - Dr. Diana Barbonta

Alba Iulia, Alba, Romania

Diabdana

Oradea, Bihor County, Romania

Centrul Medical Grandmed

Oradea, Bihor County, Romania

C.M.D.T.A. Neomed

Brasov, Brașov County, Romania

Nicodiab

Bucharest, Bucharest, Romania

Geea Medical Easy Diet

Bucharest, Bucharest, Romania

Centrul Medical NutriLife

Bucharest, Bucharest, Romania

The National Institute of Diabetes, Nutrition and Metabolic Diseases "Prof. Dr. N. Paulescu"

Bucharest, Bucharest, Romania

Gama Diamed

Mangalia, Constanța County, Romania

Top Diabet SRL

Craiova, Dolj, Romania

CMI DNBM Dr. Pop Lavinia

Baia Mare, Maramureş, Romania

SC Dentosim Queen SRL - Centrul Medical Diamed

Târgu Mureş, Mureș County, Romania

Diabmed Dr. Popescu Alexandrina

Ploieşti, Prahova, Romania

Dianutrilife Medica

Ploieşti, Prahova, Romania

Centru Medical Dr. Negrisanu

Timișoara, Timiș County, Romania

CMI Dr.Pletea Noemi SRL

Bacau, Romania

SC Minimed SRL

Bacau, Romania

Diamed Obesity

Galați, Romania

Olimpia Med

Iași, Romania

Centrul Medical Consultmed

Iași, Romania

Arkhangelsk Regional Clinical Hospital

Arkhangelsk, Arkhangelskaya oblast, Russia

First City Clinical Hospital E.E. Volosevich

Arkhangelsk, Arkhangelskaya oblast, Russia

Advisory Diagnostic Centre

Syktyvkar, Komi, Russia

City Mariinskaya Hospital

Saint Petersburg, Leningradskaya Oblast', Russia

National Medical Research Center for therapy and preventive medicine

Moscow, Moscow, Russia

Endocrinology Research Center of Rosmedtechnologies

Moscow, Moscow, Russia

Pirogov Russian National Research Medical University

Moscow, Moscow, Russia

First Moscow State Medical University I.M. Sechenov

Moscow, Moscow, Russia

Russian Cardiology Research and Production Complex

Moscow, Moscow, Russia

Moscow City Clinical Hospital Number 52

Moscow, Moscow, Russia

M. F. Vladimirskiy Moscow Regional Research Clinical Institute

Moscow, Moscow, Russia

Moscow City Clinical Hospital Number 52

Moscow, Moscow, Russia

Novosibirsk State Medical University

Novosibirsk, Novosibirsk Oblast, Russia

Rostov State Medical University

Rostov-on-Don, Rostov Oblast, Russia

Ryazan Regional Clinical Cardiological Dispensary

Ryazan, Ryazan Oblast, Russia

S.M. Kirov Military Medical Academy

Saint Petersburg, Sankt-Peterburg, Russia

Saint-Petersburg City Hospital of Saint Elizabeth

Saint Petersburg, Sankt-Peterburg, Russia

Astarta Clinic

Saint Petersburg, Sankt-Peterburg, Russia

Regional Clinical Hospital of the Saratov Region

Saratov, Saratov Oblast, Russia

Tomsk Regional Clinical Hospital

Tomsk, Tomsk Oblast, Russia

Siberian State Medical University

Tomsk, Tomsk Oblast, Russia

Research & Practice

Yaroslavl, Yaroslavl Oblast, Russia

Yaroslavl State Med Acad Clinical Hospital

Yaroslavl, Yaroslavl Oblast, Russia

IN-DIA

Lučenec, Banská Bystrica Region, Slovakia

Diacrin s.r.o.

Bratislava, Bratislava Region, Slovakia

Sin Azucar

Malacky, Bratislava Region, Slovakia

DIAB sro

Rožňava, Košice Region, Slovakia

Funkystuff

Nové Zámky, Nitra Region, Slovakia

Diabetol

Prešov, Presov, Slovakia

MED-DIA s.r.o

Sabinov, Presov, Slovakia

DIA-MED CENTRUM s.r.o.

Púchov, Trenčín Region, Slovakia

Diabetes Centrum

Trenčín, Trenčín Region, Slovakia

Yonsei University-Wonju Severance Christian Hospital

Wŏnju, Kang-won-do, South Korea

Korea University Anam Hospital