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ACTIVE NOT RECRUITING
NCT04262466
PHASE1/PHASE2

Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors

Sponsor: Immunocore Ltd

View on ClinicalTrials.gov

Summary

Brenetafusp (IMC-F106C) is an immune-mobilizing monoclonal T cell receptor against cancer (ImmTAC ®) designed for the treatment of cancers positive for the tumor-associated antigen PRAME. This is a first-in-human trial designed to evaluate the safety and efficacy of brenetafusp in adult participants who have the appropriate HLA-A2 tissue marker and whose cancer is positive for PRAME.

Official title: Phase 1/2 Study of IMC-F106C in Advance PRAME-Positive Cancers

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

410

Start Date

2020-02-25

Completion Date

2027-12

Last Updated

2026-03-06

Healthy Volunteers

No

Interventions

DRUG

Brenetafusp

Brenetafusp IV infusions

DRUG

Brenetafusp and pembrolizumab

Brenetafusp and pembrolizumab IV infusions

DRUG

Brenetafusp and chemotherapy

Brenetafusp and chemotherapy IV infusions

DRUG

Brenetafusp and monoclonal antibodies and chemotherapy

Brenetafusp and a monoclonal antibody therapy and chemotherapy

DRUG

Brenetafusp and tebentafusp

Brenetafusp and tebentafusp IV infusions

DRUG

Brenetafusp and bevacizumab

Brenetafusp and bevacizumab IV infusions

DRUG

Brenetafusp and kinase inhibitors

Brenetafusp and oral kinase inhibitors

Locations (76)

University of California - San Diego

La Jolla, California, United States

Angeles Clinic and Research Institute

Los Angeles, California, United States

University of California Davis Comprehensive Center

Sacramento, California, United States

University of Colorado

Aurora, Colorado, United States

Georgetown University Medical Center

Washington D.C., District of Columbia, United States

Houston Lee Moffitt Cancer Center & Research Institute

Tampa, Florida, United States

The University of Chicago Medical Center

Chicago, Illinois, United States

University of Iowa

Iowa City, Iowa, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey, United States

Columbia University Medical Center

New York, New York, United States

Memorial Sloan Kettering

New York, New York, United States

University of Oklahoma Peggy and Charles Stephenson Cancer Center

Oklahoma City, Oklahoma, United States

Abramson Cancer Center of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, United States

Prisma Health

Greenville, South Carolina, United States

Sarah Cannon Research Institute

Nashville, Tennessee, United States

MD Anderson Cancer Center

Houston, Texas, United States

University of Utah - Huntsman Cancer Institute

Salt Lake City, Utah, United States

University of Washington - Fred Hutchinson Cancer Center

Seattle, Washington, United States

University of Wisconsin

Madison, Wisconsin, United States

Scientia Clinical Research

Randwick, New South Wales, Australia

Melanoma Institute Australia (MIA) - The Poche Centre

Wollstonecraft, New South Wales, Australia

The Alfred Hospital

Melbourne, Victoria, Australia

Linear Clinical Research

Nedlands, Western Australia, Australia

LKH - Universitätsklinikum der PMU Salzburg

Salzburg, Austria

Universitair Ziekenhuis Brussel

Jette, Brussels Capital, Belgium

CHU de Liege

Liège, Luik, Belgium

Institut Jules Bordet

Brussels, Belgium

UZA

Edegem, Belgium

Universitair Ziekenhuis Gent

Ghent, Belgium

UZ Leuven

Leuven, Belgium

Hospital Nossa Senhora da Conceicao

Porto Alegre, Brazil

D'Or Institute for Research and Education

Rio de Janeiro, Brazil

National Cancer Institute

Rio de Janeiro, Brazil

Hospital Israelita Albert Einstein

São Paulo, Brazil

Princess Margaret Cancer Centre

Toronto, Ontario, Canada

CHUM Centre de Recherche

Montreal, Quebec, Canada

Institut Bergonie - Nouvelle-Aquitaine

Bordeaux, Gironde, France

Gustave Roussy (Institut de Cancerologie Gustave-Roussy)

Villejuif, Val De Marne, France

Universite Claude Bernard Lyon Est

Lyon, Villeurbanne, France

Hopital Saint-Louis - Centre d'Onco-Dermatologie

Paris, France

Institut Curie

Paris, France

Universitaetsklinikum Heidelberg

Heidelberg, Germany

St Vincents University Hospital

Dublin, Ireland

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Dipartimento di Medicina Interna e Scienze Mediche

Rome, Roma, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Patologia Ostetrica e Ginecologica

Seriate, Roma, Italy

Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale

Naples, Italy

Netherlands Cancer Institute

Amsterdam, CX, Netherlands

UMC Groningen Comprehensive Cancer Center

Groningen, GZ, Netherlands

Leiden UMC

Leiden, ZA, Netherlands

New Zealand Clinical Research-Auckland

Auckland, New Zealand

Centrum Medyczne Pratia Poznan - Skorzewo

Skórzewo, Poland

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

Warsaw, Poland

Seoul National University Hospital

Seoul, South Korea

Yonsei University College of Medicine

Seoul, South Korea

University of Ulsan College of Medicine

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Pamplona

Pamplona, Navarre, Spain

NEXT Barcelona

Barcelona, Spain

Hospital Universitario Vall dHebron

Barcelona, Spain

Hospital Duran i Reynals

Barcelona, Spain

Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Madrid

Madrid, Spain

Hospital Universitario Fundacion Jimenez Diaz

Madrid, Spain

University Hospital, Basel Switzerland

Basel, Switzerland

Centre Hospitalier Universitaire Vaudois Lausanne

Lausanne, Switzerland

University Hospital of Zurich

Zurich, Switzerland

Sarah Cannon Research Institute UK

London, City of London, United Kingdom

University of Oxford

Oxford, Oxfordshire, United Kingdom

The Beatson West of Scotland Cancer Centre

Glasgow, Scotland, United Kingdom

University of Liverpool

Liverpool, United Kingdom

University College Hospital London

London, United Kingdom

Guy's and St Thomas' NHS Foundation Trust

London, United Kingdom

The Christie NHS Foundation Trust

Manchester, United Kingdom

Royal Marsden Hospital

Surrey Quays, United Kingdom